ESTROGEN INDUCED PROTEINS IN VASCULAR SMOOTH MUSCLE

血管平滑肌中雌激素诱导的蛋白质

• 批准号: 6246124
• 负责人: LAWRENCE HORWITZ
• 金额: $ 1.71万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246124
• 关键词: estrogens; hormone regulation /control mechanism; hormone therapy; human subject; protein biosynthesis; vascular smooth muscle

The investigators propose that estrogens induce expression of proteins in coronary smooth muscle which inhibit the smooth muscle proliferation associated wtih atherogenesis. Their study aims to identify these estrogen-induced proteins via molecular techniques, utilizing smooth muscle cells from men & postmenopausal women not on HRT after exposing the cells to estrogen. Based on the findings, levels of mRNA's will be measured in men and postmenopausal women not on HRT & compared to levels in postmenopausal women on HRT or premenopausal women.

研究人员提出，雌激素诱导蛋白质的表达， 抑制冠脉平滑肌增殖 与动脉粥样硬化有关。 他们的研究旨在确定这些 雌激素诱导的蛋白质通过分子技术，利用平滑 来自男性和绝经后女性的肌肉细胞，在暴露于 细胞转化为雌激素。 根据研究结果，mRNA的水平将是 测量男性和绝经后妇女没有HRT &比较水平 在绝经后接受HRT的妇女或绝经前妇女中。