CHOLESTEROL METABOLISM IN PLASMA LIPOPROTEINS AND LIVER

血浆脂蛋白和肝脏中的胆固醇代谢

• 批准号: 6246015
• 负责人: Charles E Schwartz
• 金额: $ 2.76万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246015
• 关键词: Niemann Pick disease; blood lipoprotein; cholesterol; clinical research; human subject; hypercholesterolemia; intracellular transport; liver metabolism; lysosomes; sitosterols; vesicle /vacuole

To identify in vivo kinetic abnormalities of hepatic intracellular cholesterol traffic in sitosterolemia and Niemann-Pick Disease type C. Three isotopic compounds will be used to trace the cholesterol in three distinct cellular sites (plasma membrane, lysosome, and newly synthesized ER membrane vesicles). Results will be quantitated by compartmental analysis and compared to normal subjects.

目的：探讨肝细胞内动力学异常