CORE--BIOSTATISTICAL/METHODOLOGIC/OUTCOME ASSESMENT/COMPUTER SCIENCE

这一核心提供行政、生物统计、流行病学、健康 为所有人提供经济、技术援助和计算机科学支持 这项建议的项目。它延续了它所服务的功能 在Aramis项目的前20年有效地进行，并建立了一个 为提出的工作和未来的工作提供平台。此核心负责 中央成果评估、数据质量控制和后续行动 活动。它有责任严格和及时地履行 所有项目任务，并监控每个项目从开始到 患者招募，通过健康评估进行结果评估 调查问卷(HAQ)、数据质量控制、分析、手稿 准备和出版。它开发并提供了通用的 词典、乐器和项目协议。在这个核心中， 代表了Aramis的连续性，我们充分发展了 多年来，项目调查人员之间富有成效的合作， Aramis对发展研究问题的贡献 并具体说明我们对生物统计学和生物统计学的一般方法 卫生经济学分析。

This core provides administrative, biostatistical, epidemiologic, health economics, technical assistance, and computer science support to all projects of this proposal. It continues the functions it has served effectively over the first 20 years of the ARAMIS Project and builds a platform for proposed and future work. This Core is responsible for central outcome assessment, data quality control and follow-up activities. It has responsibility for rigorous and timely performance of all Project tasks, and monitors each project from inception through patient recruitment, outcome assessment by Health Assessment Questionnaire (HAQ), data quality control, analyses, manuscript preparation, and publication. It develops and provides the common dictionaries, instruments, and project protocols. In this Core, representing ARAMIS continuity, we fully develop the history of productive collaboration between Program Investigators over the years, the contributions of ARAMIS to development of the research questions to be addressed, and specify our general approaches to biostatistical and health economics analyses.