Discovery, preclinical and translational research in endometrial cancer

我的研究项目集中在子宫癌“从实验室到临床”的转化研究。具体来说，确定子宫癌发展背后的基因畸变，了解这些基因在正常细胞和癌细胞中的功能，为靶向这些缺陷蛋白的药物在体外和体内诱导癌细胞死亡提供原理数据的证据，并确定与患者是否对一种特定治疗有反应相关的因素。

My research program is focused on “bench to bedside” translational research in uterine cancer. Specifically, identifying the genetic aberrations underlying the development of uterine cancer, understanding the function of these genes in normal and cancer cells, providing proof of principle data that drugs targeting these defective proteins induce cancer cell death in vitro and in vivo and identifying factors associated with whether a patient will respond to one particular treatment over another.