Discovery, preclinical and translational research in endometrial cancer

我的研究项目集中在子宫癌的“长凳到床边”的翻译研究上。具体地说，识别导致子宫癌发生的基因异常，了解这些基因在正常细胞和癌细胞中的功能，提供针对这些缺陷蛋白的药物在体外和体内导致癌细胞死亡的原理数据的证据，并确定与患者对一种特定治疗是否比对另一种治疗有反应的相关因素。

My research program is focused on “bench to bedside” translational research in uterine cancer. Specifically, identifying the genetic aberrations underlying the development of uterine cancer, understanding the function of these genes in normal and cancer cells, providing proof of principle data that drugs targeting these defective proteins induce cancer cell death in vitro and in vivo and identifying factors associated with whether a patient will respond to one particular treatment over another.