Discrete simulation of powder dispersion in pharmaceutical aerosol inhalers

药物气雾吸入器中粉末分散的离散模拟

• 批准号: nhmrc : 571277
• 负责人: Mr Santoso Adi
• 金额: $ 2.34万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discrete-simulation-powder-aerosol-inhalers/116192
• 关键词: Discrete; simulation; powder; dispersion; pharmaceutical

This project seeks to develop fundamental understanding of the dispersion mechanisms of powders as aerosol for inhalation drug delivery. It couples computational simulations using computational fluid dynamics and discrete element method with experimental dispersion analysis. Successful development of this research will lead to a comprehensive understanding of factors controlling inhaler performance and thus maximizes the therapeutic benefits to the patients.

本项目旨在发展对粉末作为吸入给药气雾剂的分散机制的基本理解。它耦合使用计算流体动力学和离散元方法与实验色散分析的计算模拟。这项研究的成功发展将导致对控制吸入器性能的因素的全面了解，从而最大限度地提高患者的治疗获益。