SPECT IMAGING OF STRIATAL DOPAMINE WITH IBZM D-AMPHETAMINE & AMPT

使用 IBZM D-安非他明对纹状体多巴胺进行 SPECT 成像

• 批准号: 6220091
• 负责人: MARC A LARUELLE
• 金额: $ 0.04万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220091
• 关键词: amphetamines; bioimaging /biomedical imaging; clinical research; dopamine; human subject; neurochemistry; neurotransmitter transport; schizophrenia; single photon emission computed tomography

This proposal will provide in two scans a complete characterization of dopaminergic function in 45 patients with schizophrenia compared to 45 matched healthy controls. We will compare D-amphetamine induced DA release & AMPT induced DA depletion between patients with schizophrenia compared to healthy controls.

这项提案将在两次扫描中提供完整的特征 45例精神分裂症患者的多巴胺能功能与45例的比较 与健康对照组相匹配。我们将比较D-苯丙胺引起的DA 精神分裂症患者释放和氨甲喋呤引起的多巴胺耗竭 与健康对照组相比。