ACTG 360: OBSERVATIONAL STUDY OF CMV & HIV VIRAL BURDEN

ACTG 360：CMV 观察性研究

• 批准号: 6265409
• 负责人: DAVID IVES
• 金额: $ 2.98万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265409
• 关键词: AIDS therapy; HIV infections; clinical research; cytomegalovirus; disease /disorder proneness /risk; human subject; virus replication

This is an observational study of HIV-infected subjects who are CMV-seropositive and who have not had clinical symptoms of CMV disease at study entry to 1) define relationships between HIV load and risk of CMV disease; CMV load and the risk of developing CMV disease; and CMV load and HIV load. 2) To establish threshold CMV and HIV load values in peripheral blood fractions that are associated with development of CMV end-organ disease. 3) To define the natural history of CMV infaction in the context of highly active antiretroviral therapy (HAART).

这是一项观察性研究，受试者为CMV血清阳性且在入组研究时未出现CMV疾病临床症状的HIV感染受试者，目的是1）确定HIV载量与CMV疾病风险之间的关系; CMV载量与发生CMV疾病的风险之间的关系;以及CMV载量与HIV载量之间的关系。 2)确定外周血组分中与CMV终末器官疾病发生相关的CMV和HIV载量阈值。 3)明确高效抗逆转录病毒治疗（HAART）背景下CMV感染的自然史。