CGP 57148B 在慢性粒细胞白血病患者中的应用-猫眼课题宝

CGP 57148B 在慢性粒细胞白血病患者中的应用

批准号：

6265343

负责人：

CHARLES SAWYER

金额：

$0.19万

依托单位：

UNIVERSITY OF CALIFORNIA LOS ANGELES

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-12-01 至 1999-11-30

来源：

https://reporter.nih.gov/project-details/6265343

关键词：

antineoplastics chronic myelogenous leukemia clinical research clinical trial phase I dosage drug screening /evaluation enzyme inhibitors human subject human therapy evaluation leukocytes neoplasm /cancer chemotherapy oral administration pharmacokinetics piperazines protein tyrosine kinase pyrimidines western blottings

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英文摘要

The primary objectives are: a) to assess the safety and tolerability, and to establish the maximum tolerated dose of CGP 57148B when administered orally to Ph chromosome positive CML patients in chronic-phase who are resistant to interferon-alpha, and b) to obtain pharmacokinetic profiles at different escalating doses. The secondary objectives are: a) to obtain preliminary evidence of anti-leukemic activity as shown by a decrease in peripheral white blood cell counts and the peripheral white blood cell counts and the percentage of Ph chromosome positive cells in the bone marrow, and b) to obtain preliminary evidence of inhibition of the tyrosine kinase activity of the chimeric Bcr-Abl protein using a phosphotyrosine immunoblot assay.

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