CORE--CLINICAL

核心--临床

• 批准号: 6334863
• 负责人: LADISLAV VOLICER
• 金额: $ 31.28万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6334863
• 关键词: Alzheimer's disease; DNA; apolipoprotein E; behavioral /social science research tag; biomedical facility; blood chemistry; brain cell; caregivers; clinical research; computer data analysis; dementia; disease /disorder classification; disease /disorder proneness /risk; family; functional ability; genotype; human old age (65+); human subject; information dissemination; longitudinal human study; minority health professional; neuropsychological tests; postmortem; questionnaires; sign /symptom; tissue /cell culture

The Clinical Core will define the neuropsychological and neurological attributes of the two patient populations enrolled in the Boston University Alzheimer's Disease Research Center (BU ADCC). The Bedford VA Medical Center is a source of institutionalized patients with late stage Alzheimer's disease (AD) and ambulatory patients with earlier stages of dementia. Unlike the typical Alzheimer clinic in an acute hospital setting, patients are not lost to follow up and close contact is maintained with caregivers throughout all stages of the disease. This close relationship is a patient/family and provider partnership that has facilitated the recruitment of patients and caregivers into several research projects and has sustained an autopsy rate of 75% over the past 6 years. This exemplary standard of care and research will be applied to characterize the racially, ethnically and culturally diverse poor urban population served by the Boston University Home Medical Service (HMS). In contrast to the population served at the Bedford VA Medical Center, which is homogenous and middle class, about 40% of HMS patients are not caucasian, 60% are on Medicaid and 72% are female. All HMS patients receive a complete medical evaluation which will be reviewed to identify early stage or presymptomatic patients for enrollment in the clinical core. Enrolled subjects at the Bedford VA and the HMS will undergo a standardized, validated one hour neuropsychological evaluation every 6 months and an annual neurological evaluation and blood drawing. DNA will be extracted and stored and Apo E genotype will be determined. In selected cases, lymphoblastic cell lines will be created. All data collected will be entered into a standardized database. In conjunction with a major aim of the Education Core, patients and control subjects will be encouraged to donate their brains for research purposes. Family caregivers will be enrolled and a standardized assessment of caregiver burden will be performed annually. This database will provide a foundation for future research on interventions to reduce caregiver burden and studies concerning the emotional and financial impact of AD.

临床核心将定义神经心理学和神经系统 波士顿注册的两个患者人群的属性 阿尔茨海默氏病大学疾病研究中心（BU ADCC）。 贝德福德·弗吉尼亚州 医疗中心是晚期制度化患者的来源 阿尔茨海默氏病（AD）和卧床患者的早期阶段 失智。 与急性医院的典型阿尔茨海默氏症诊所不同 设置，病人不会失去随访，紧密接触是 在整个疾病的所有阶段都保持护理人员的维护。 这 亲密关系是患者/家庭和提供商的合作伙伴关系 促进了患者和看护人的招募 研究项目，过去的尸检率为75％ 6年。 这种典范的护理标准和研究将应用于 在种族，种族和文化上的贫穷城市上表征 波士顿大学家庭医疗服务（HMS）服务的人口。 在 与贝德福德弗吉尼亚州医疗中心服务的人口形成对比，该中心 是同质和中产阶级，大约40％的HMS患者不是 高加索人，有60％的医疗补助为女性。 所有HMS患者 接受完整的医学评估，将审查以识别 早期或症状性患者参加临床 核。 弗吉尼亚州贝德福德（Bedford VA）和HMS的招募对象将经历 每6个标准化，经过验证的一小时神经心理学评估 月份和年度神经学评估和血液绘画。 DNA会 将被提取并存储，并确定APO E基因型。 在 选定的病例，将创建淋巴细胞细胞系。 所有数据 收集的将输入标准化数据库。 结合 以教育核心的主要目的，患者和控制科目将 鼓励为研究目的捐赠大脑。 家庭 护理人员将被注册，并对护理人员进行标准化评估 负担将每年进行。 该数据库将提供 未来研究干预措施以减轻照料者负担的基础 以及有关AD的情感和财务影响的研究。