CORE--GENETIC LINKAGE AND EPIDEMIOLOGY

遗传连锁和流行病学核心负责 组织科学数据的流动并保持其完整性， 为了在统计遗传学中进行必要的分析， 尤其是遗传连锁分析。预计在大多数情况下 需要使用这个核心的项目，疾病基因将必须 定位在人类基因图谱上。为此，对于特定的疾病， 项目，家谱将由相应的项目收集 导演和标记的基因分型将在分子中确定 遗传学核心。然后每个个体的表型和基因数据 需要在核心和设施的计算机中输入 将根据链接的简易性进行链接分析 程序。

The Genetic Linkage and Epidemiology Core is responsible for the organizing the flow of scientific data and maintaining its integrity, and for carrying out the necessary analyses in statistical genetics, particularly genetic linkage analysis. It is expected that in most projects requiring use of this Core, disease genes will have to be localized on the human gene map. To this end, for a given disease project, family pedigrees will be collected by the corresponding project director, and marker genotypes will-be determined in the molecular genetics Core. Phenotype and genotype data for each individual then needs to be entered in a computer at the facilities of the Core and linkage analysis will be carried out with the ease of the LINKAGE programs.