ANOGENITAL CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, AND IMMUNOLOGY
ANOGENITAL CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, AND IMMUNOLOGY
批准号:
6102322
负责人:
JANET R DALING
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-06-01 至 1999-05-31
关键词:
antiviral antibody biochemistry cancer risk cervix neoplasms herpes simplex virus 2 human papillomavirus human subject interview neoplasm /cancer epidemiology neoplasm /cancer immunology oral contraceptives rectum neoplasms reproductive system neoplasm serology /serodiagnosis sex behavior sexually transmitted diseases statistics /biometry tobacco abuse vagina neoplasms viral carcinogenesis virus DNA vulva neoplasms western blottings
中文摘要
这是一项继续进行病例对照研究的建议,
人乳头瘤病毒(HPV)在肛门生殖器发育中的作用
癌的该研究将主要在以下三个县进行:
华盛顿西部被以人口为基础的癌症所覆盖
监测系统(CSS),一个肿瘤登记处,参与了
国家监测流行病学和最终结果方案
癌症研究所.(阴茎、宫颈原位腺癌,以及
将包括另外10个县的阴道癌,
足够的样本量)。所有18-74岁的男性和女性,
恶性肿瘤将被确定并邀请参加,我们
预计成功面谈的个案数目如下:
宫颈浸润癌248例,肛门及肛周癌108例
外阴癌164例,阴茎癌48例,
宫颈腺癌96例,阴道癌60例
cases).合格的受试者将是所有诊断为
在1994年7月至1998年6月的五年期间,这六种癌症。
将对病例和适当的对照组进行访谈,了解
性传播疾病,以及其他已知的风险因素,
每一个特定的网站。手术组织标本将从以下地点获得
所有的病例,并将探测人类乳头瘤病毒的证据,
分子杂交技术将采集血液样本,
所有病例和对照,并分析既往暴露于
单纯疱疹病毒2型和目前使用的几种类型的HPV
可用的测试将冷冻额外的血清以备将来测定
HPV抗体作为新的和/或更敏感的血清学检测,
为HPV而开发。
英文摘要
This is a proposal to continue our case-control studies investigating the
role of human papillomaviruses (HPV) in the development of anogenital
cancers. The study will be conducted primarily in three counties of
Western Washington that are covered by the population-based Cancer
Surveillance System (CSS), a tumor registry that participates in the
Surveillance Epidemiology and End Results Program (SEER) of the National
Cancer Institute. (Penile, adenocarcinoma in situ of the cervix, and
vaginal cancers from ten additional counties will be included to provide
a sufficient sample size.) All men and women aged 18-74 with one of six
malignancies will be identified and invited to participate, and we
estimate the following number of cases will be successfully interviewed:
invasive cancer of the cervix (248 cases); anal and perianal cancer (108
cases); vulvar cancer (164 cases); penile cancer (48 cases);
adenocarcinoma of the cervix (96 cases); and cancer of the vagina (60
cases). Eligible subjects will be all individuals with a diagnosis of one
of these six cancers during a five-year period from July 1994 - June 1998.
Cases and appropriate controls will be interviewed regarding a history of
sexually-transmitted diseases, as well as other known risk factors for
each specific site. Tissue specimens from surgery will be obtained from
all cases and will be probed for evidence of human papillomavirus using
molecular hybridization techniques. Blood samples will be collected for
all cases and controls and analyzed for evidence of prior exposure to
herpes simplex virus type 2 and for several types of HPV using currently
available tests. Additional sera will be frozen for future determination
of HPV antibodies as new and/or more sensitive serologic tests are
developed for HPV.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
EPIDEMIOLOGY OF HPV-RELATED SCSC IN TRANSPLANT PATIENTS
-
批准号:7300320
-
项目类别:
-
资助金额:$52.29万
-
财政年份:2007
-
负责人:JANET R DALING
-
依托单位:
Tamoxifen & Second Breast Cancer: Epidemiology/Pathology
-
批准号:6756560
-
项目类别:
-
资助金额:$69.5万
-
财政年份:2003
-
负责人:JANET R DALING
-
依托单位:
Tamoxifen & Second Breast Cancer: Epidemiology/Pathology
-
批准号:6619122
-
项目类别:
-
资助金额:$70.0万
-
财政年份:2003
-
负责人:JANET R DALING
-
依托单位:
ANOGENITAL CANCER--EPIDEMIOLOGY/BIOCHEMISTRY/IMMUNOLOGY
-
批准号:6580339
-
项目类别:
-
资助金额:$28.07万
-
财政年份:2002
-
负责人:JANET R DALING
-
依托单位:
HRT USE AND RISK OF LOBULAR AND DUCTAL BREAST CANCER
-
批准号:6377823
-
项目类别:
-
资助金额:$57.64万
-
财政年份:2000
-
负责人:JANET R DALING
-
依托单位:
HRT USE AND RISK OF LOBULAR AND DUCTAL BREAST CANCER
-
批准号:6556281
-
项目类别:
-
资助金额:$7.38万
-
财政年份:2000
-
负责人:JANET R DALING
-
依托单位:
HRT USE AND RISK OF LOBULAR AND DUCTAL BREAST CANCER
-
批准号:6603759
-
项目类别:
-
资助金额:$57.83万
-
财政年份:2000
-
负责人:JANET R DALING
-
依托单位:
HRT USE AND RISK OF LOBULAR AND DUCTAL BREAST CANCER
-
批准号:6765901
-
项目类别:
-
资助金额:$45.8万
-
财政年份:2000
-
负责人:JANET R DALING
-
依托单位:
HRT USE AND RISK OF LOBULAR AND DUCTAL BREAST CANCER
-
批准号:6091297
-
项目类别:
-
资助金额:$47.97万
-
财政年份:2000
-
负责人:JANET R DALING
-
依托单位:
HRT USE AND RISK OF LOBULAR AND DUCTAL BREAST CANCER
-
批准号:6514470
-
项目类别:
-
资助金额:$62.68万
-
财政年份:2000
-
负责人:JANET R DALING
-
依托单位:
ANOGENITAL CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, AND IMMUNOLOGY
-
批准号:6340760
-
项目类别:
-
资助金额:$28.07万
-
财政年份:1999
-
负责人:JANET R DALING
-
依托单位:
ANOGENITAL CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, AND IMMUNOLOGY
-
批准号:6203112
-
项目类别:
-
资助金额:$28.07万
-
财政年份:1999
-
负责人:JANET R DALING
-
依托单位:
CALCIUM CHANNEL BLOCKERS IN BREAST CANCER ETIOLOGY
-
批准号:6150243
-
项目类别:
-
资助金额:$51.53万
-
财政年份:1997
-
负责人:JANET R DALING
-
依托单位:
CALCIUM CHANNEL BLOCKERS IN BREAST CANCER ETIOLOGY
-
批准号:6350209
-
项目类别:
-
资助金额:$18.88万
-
财政年份:1997
-
负责人:JANET R DALING
-
依托单位:
CALCIUM CHANNEL BLOCKERS IN BREAST CANCER ETIOLOGY
-
批准号:2450041
-
项目类别:
-
资助金额:$40.26万
-
财政年份:1997
-
负责人:JANET R DALING
-
依托单位:
CALCIUM CHANNEL BLOCKERS IN BREAST CANCER ETIOLOGY
-
批准号:2871920
-
项目类别:
-
资助金额:$54.01万
-
财政年份:1997
-
负责人:JANET R DALING
-
依托单位:
CALCIUM CHANNEL BLOCKERS IN BREAST CANCER ETIOLOGY
-
批准号:2654247
-
项目类别:
-
资助金额:$59.47万
-
财政年份:1997
-
负责人:JANET R DALING
-
依托单位:
ANOGENITAL CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, AND IMMUNOLOGY
-
批准号:6236843
-
项目类别:
-
资助金额:$26.54万
-
财政年份:1997
-
负责人:JANET R DALING
-
依托单位:
FACTORS AFFECTING SURVIVAL OF YOUNG CANCER PATIENTS
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批准号:2100339
-
项目类别:
-
资助金额:$28.89万
-
财政年份:1993
-
负责人:JANET R DALING
-
依托单位:
FACTORS AFFECTING SURVIVAL OF YOUNG CANCER PATIENTS
-
批准号:2100340
-
项目类别:
-
资助金额:$30.04万
-
财政年份:1993
-
负责人:JANET R DALING
-
依托单位:
海外基金