ELUCIDATION OF CHEMICAL STRUCTURES AND LARGE-SCALE SYNTHESIS OF CHEMOPROTECTORS

化学结构的阐明和化学保护剂的大规模合成

• 批准号: 6269280
• 负责人: GARY H POSNER
• 金额: $ 21.82万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6269280
• 关键词: biomedical facility; carcinogenesis inhibitor; chemical structure; drug design /synthesis /production; isothiocyanates

This Core facility provides analytical and synthetic expertise, and is specifically organized for three purposes: (a) the elucidation of chemical structures of chemoprotective enzyme inducers isolated from edible plants (Project No. 1); (b) the multigram synthesis of enzyme inducers isolated from plants (projects No.1), or identified by structure-activity studies, for evaluation as anticarcinogens in animal models (Project No. 1 and No. 3); and (c) the multigram synthesis of previously designed or identified Phase 2 enzyme inducers or their analogs for evaluation as anticarcinogens in animal systems (Project No. 1 and No. 3).

该核心设施提供分析和综合专业知识，并且是