Dissecting the mechanisms of vaccine immunogenicity and induction of protective immunity against influenza virus

剖析疫苗免疫原性和诱导流感病毒保护性免疫的机制

• 批准号: nhmrc : 1072127
• 金额: $ 24.35万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-mechanisms-vaccine-influenza-virus/455492
• 关键词: Dissecting; mechanisms; vaccine; immunogenicity; induction

Influenza pandemics have historically led to worldwide morbidity and mortality. Vaccination remains to be the only plausible strategy to limit widespread mortality as a result of an influenza pandemic. The parts of the immune system important in protecting individuals from influenza virus are poorly understood. This research aims to understand the important correlates of protective immunity in order to improve vaccine design.

流感大流行历来导致世界范围的发病率和死亡率。疫苗接种仍然是限制流感大流行造成的广泛死亡的唯一可行策略。免疫系统中保护个体免受流感病毒侵害的重要部分了解甚少。本研究旨在了解保护性免疫的重要相关因素，以改进疫苗设计。