Dissecting the molecular basis for emerging alcohol tolerance in VRE

剖析 VRE 中出现的酒精耐受性的分子基础

• 批准号: nhmrc : GNT1084015
• 负责人: A/Pr Torsten Seemann
• 金额: $ 80.47万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-molecular-basis-tolerance-vre/1345536
• 关键词: Dissecting; molecular; basis; emerging; alcohol

Infections caused by vancomycin resistant Enterococcus faecium (VREfm) are a major and growing problem in health care facilities around Australia. We have observed that VREfm is becoming significantly more resistant to killing by alcohol, probably due the increasing use of alcohol-based hand wash products. This project will identify how VREfm is becoming alcohol tolerant, knowledge that will be used to develop alternative disinfection methods or other intervention strategies to stop its spread.

万古霉素耐药屎肠球菌（VREfm）引起的感染是澳大利亚各地卫生保健设施中一个日益严重的主要问题。我们观察到，VREfm对酒精致死的抵抗力正在显著增强，这可能是由于越来越多地使用含酒精的洗手产品。该项目将确定VREfm如何成为酒精耐受性，这些知识将用于开发替代消毒方法或其他干预策略，以阻止其传播。