Dissecting the molecular basis for cell movement and midgut colonisation in the insect stage parasite - the ookinete

剖析昆虫阶段寄生虫——动合子的细胞运动和中肠定植的分子基础

• 批准号: nhmrc : 1055246
• 负责人: Miss Fiona Angrisano
• 金额: $ 3.23万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-molecular-basis-parasite-ookinete/112441
• 关键词: Dissecting; molecular; basis; cell; movement

Malaria parasites are a leading cause of infant mortality. Despite their global impact, no vaccine exists to prevent malaria disease and resistance to current drugs is prevalent. Cell movement is an essential process for parasite development yet its potential as a drug target remains unexplored. I seek to shed light on the molecular mechanisms underlying movement, focused on the motile insect stages. Understanding gained here will support the broader goal to identify targets for transmission-blocking development.

疟疾寄生虫是婴儿死亡的主要原因。尽管它们具有全球影响，但没有预防疟疾的疫苗，而且对现有药物的耐药性普遍存在。细胞运动是寄生虫发育的重要过程，但其作为药物靶点的潜力尚未被探索。我试图阐明运动的分子机制，集中在运动昆虫的阶段。在此获得的理解将支持确定传输阻断发展目标的更广泛目标。