GENERAL CLINICAL RESEARCH CENTER

埃默里大学的综合临床研究中心有一个长期的 杰出的临床研究历史。 这项工作的主要目的是 5-一年续约申请是提供设施和资源 现有的和越来越多的未完成的新任务， 基础科学和临床研究人员可以追求的重要领域， 临床研究 研究的具体目标和主要领域 在涉及76名研究人员的44项定义的方案中概述了拟议的方案。 其中包括：1）慢性肝病及其并发症的研究 如代谢性骨病;肝功能研究， 肝脏疾病的血液动力学，包括肝脏的影响 移植和调节血液动力学的各种 药物; 2）肾脏疾病的研究，包括 营养干预可能延缓进展的机制 终末期肾病; 3）内分泌学研究，包括肥胖; 葡萄糖和乳酸代谢的改变;胰岛素抵抗， 糖尿病;胰岛素受体基因调控;治疗试验 生长激素;生长调节素的营养调节， 生长调节素抑制剂; 4）血液学/肿瘤学研究，包括 血小板生成和破坏的研究; 5） 心脏病学，比较球囊血管成形术与旁路移植术， 冠状动脉疾病的治疗; 6）遗传性疾病的研究 包括线粒体肌病，以及 研究核突变的分子方法，如Emery-Dreifuss 肌营养不良症;和7）先天性代谢缺陷的研究， 特别是生产枫糖浆的酶和分子机制 尿病、苯丙酮尿症、血色素沉着症和卟啉症。 总的来说， 这些项目侧重于重要的医疗、外科和儿科健康 新的发现和治疗方法可能会产生重大影响的疾病 冲击 为了实现这些目标，我们提供了一个优秀的团队， 新的研究人员，来自埃默里大学的大量患者资料， 附属医院和诊所，一个严格管理的12张病床的临床 拥有经验丰富的研究护士的研究机构，核心实验室 具有代谢平衡研究的专业知识，营养/热量测量团队 和代谢厨房，一个新开发和装备的分子生物学 实验室，一个高度组织化的生物统计支持单位， 计算机资源，以及一所致力于追求卓越的大学 在研究中。

The General Clinical Research Center of Emory University has a long history of outstanding clinical research. The primary objective of this 5-Year renewal application is to provide the facilities and resources whereby both the existing and an increasing number of outstanding new basic science and clinical investigators can pursue important areas of clinical research. The specific aims and major areas of research proposed are outlined in 44 defined protocols involving 76 investigators. These include: 1) studies on chronic liver diseases and complications such as metabolic bone disease; studies of hepatic function and hemodynamics in liver disease, including the effects of liver transplantation and modulation of hemodynamics by a variety of pharmacologic agents; 2) studies of kidney disease, including the mechanisms by which nutritional intervention might retard progression to end-stage renal disease; 3) studies in endocrinology, including obesity; alterations in glucose and lactate metabolism; insulin resistance and diabetes; genetic regulation of insulin receptors; therapeutic trials with growth hormone; and nutritional regulation of somatomedin and somatomedin inhibitors; 4) studies in hematology/oncology, including investigation of platelet production and destruction; 5) studies in cardiology, comparing balloon angioplasty with bypass graft surgery for treatment of coronary artery disease; 6) studies of inherited disorders of mitochondrial function, including the mitochondrial myopathies, and molecular approaches to nuclear mutations such as the Emery-Dreifuss muscular dystrophy; and 7) studies of inborn errors of metabolism, especially the enzymatic and molecular mechanisms producing maple syrup urine disease, phenylketonuria, hemochromatosis and porphyria. Overall, these projects focus on important medical, surgical and pediatric health disorders for which new discoveries and treatments could have a major impact. To accomplish these aims, we offer an outstanding team of existing and new investigators, a wealth of patient material from the Emory University Affiliated Hospitals and Clinic, a tightly administered 12-bed clinical research facility with experienced research nurses, a core laboratory with expertise in metabolic balance studies, a nutrition/calorimetry team and metabolic kitchen, a newly developed and equipped molecular biology laboratory, a highly organized biostatistical support unit and CLINFO computer resource, and a University with a vital commitment to excellence in research.