ANTIOXIDANT RESPONSE TO VITAMIN E ADMINISTRATION

本研究的主要目的是确定抗氧化剂的特性。 补充维生素E的效果。为此，两部在体小说 氧化应激的标志物将被测量：8-epi-PGF(2α)和8-epi-PGF OXODG。研究的具体目标是：i)确定 达到最大抗氧化效果所需的最佳剂量的维生素E。 Ii)确定达到最大抗氧化剂效果的时间进程 确定下列抗氧化作用的持续时间 停用维生素E IV)比较两种新药的疗效 氧化应激的标志物。

The primary objective of this study is to characterize the antioxidant effect of Vitamin E supplementation. To this end two novel in vivo markers of oxidative stress will be measured: 8-epi-PGF (2 alpha) and 8- oxodG. The specific objectives of the study are: i) to determine the optimum dose of vitamin E required to reach maximum antioxidant effect. ii) to establish the time course to reach maximal antioxidant effect iii) to establish the duration of the antioxidant effect following discontinuation of vitamin E iv) to compare the efficacy of two novel markers of oxidative stress.