ANTIOXIDANT RESPONSE TO VITAMIN E ADMINISTRATION

服用维生素 E 的抗氧化反应

• 批准号: 2783161
• 金额: $ 2.45万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2783161
• 关键词: alternative medicine; antioxidants; biomarker; clinical research; dietary supplements; dosage; eicosanoids; human subject; nutrition related tag; oxidative stress; tocopherols

The primary objective of this study is to characterize the antioxidant effect of Vitamin E supplementation. To this end two novel in vivo markers of oxidative stress will be measured: 8-epi-PGF (2 alpha) and 8- oxodG. The specific objectives of the study are: i) to determine the optimum dose of vitamin E required to reach maximum antioxidant effect. ii) to establish the time course to reach maximal antioxidant effect iii) to establish the duration of the antioxidant effect following discontinuation of vitamin E iv) to compare the efficacy of two novel markers of oxidative stress.

本研究的主要目的是表征抗氧化剂 补充维生素E的效果。 为此两部小说在体内 将测量氧化应激标记物：8-epi-PGF (2 α) 和 8- 氧化G。 研究的具体目标是： i) 确定 达到最大抗氧化效果所需的维生素E最佳剂量。 ii) 确定达到最大抗氧化效果的时间进程 iii) 确定以下抗氧化作用的持续时间 停用维生素 E iv) 来比较两种新型药物的功效 氧化应激的标志物。