VIRAL GENES AS TARGETS FOR ANTIVIRAL DRUGS

我们研究的总体目标是确定新的化合物 有可能成为有用的抗病毒药物并研究 前景看好的化合物在细胞、分子和生化方面的作用 水平。为此，我们通过体外选择方法衍生出 人巨细胞病毒和人类免疫缺陷病毒 对活性化合物具有抗药性的菌株。利用抗药性 作为一个标志物，我们正在确定哪一种人巨细胞病毒和艾滋病毒 基因发生了突变，产生了抗药性病毒株。 对这类基因的识别提供了对 抗病毒药物的作用。此外，由基因指定的蛋白质 可能成为抗病毒药物的新靶点。具体目标 需要使用GCG分析软件进行序列比对 病毒基因与相关病毒、哺乳动物和原核生物基因的关系 为了更好地了解病毒基因的功能和病毒的作用 新的抑制剂。

The overall objective of our research is to identify new compounds which have the potential to become useful antiviral drugs and to investigate how promising compounds act at the cellular, molecular and biochemical level. Toward this end, we have derived by in vitro selection methods human cytomegalovirus (HCMV) and human immunodeficiency virus (HIV) strains which are resistant to active compounds. Using drug resistance as a marker, we are in the process of identifying which HCMV and HIV genes have mutated to produce drug resistant virus strains. Identification of such genes is providing detailed understanding of antiviral drug action. Furthermore, the proteins specified by the genes may be new targets for antiviral drugs. The specific objective requiring the use of GCG analysis software is to compare the sequence of the viral genes to related viral, mammalian, and prokaryotic genes to better understand the function of the viral gene and the action of new inhibitors.