INVESTIGATION OF A POSSIBLE ASSOCIATION BETWEEN MYCOPLASMA SPECIES AND ASTHMA

哮喘是一种以呼吸道可逆为特征的临床综合征。 阻塞、呼吸道炎症和对多种疾病的高反应性 刺激物。然而，其发病机制仍不明确。 某些微生物被认为与哮喘的恶化有关， 尤其是病毒、衣原体和肺炎支原体。几个 研究表明，感染肺炎支原体会导致 非哮喘患者的支气管高反应性和气流阻塞 感染后可持续数年的患者。此外，一个 与哮喘相似的呼吸道疾病动物模型可以用 肺支原体。我们假设慢性、稳定的患者 哮喘会在上半身和下半身表现出支原体。 航空公司。此外，克拉霉素是一种大环内酯类药物， 已知的抗支原体活性，将导致 他们的哮喘。

Asthma is a clinical syndrome characterized by reversible airway obstruction, airway inflammation and hyperresponsiveness to a wide variety of stimuli. However, the pathogenesis has remained poorly defined. Certain microorganisms have been implicated in the exacerbation of asthma, particularly viruses, chlamydia and Mycoplasma pneumoniae. Several studies have shown that infection with M. pneumoniae results in increased bronchial hyperresponsiveness and airflow obstruction in non-asthmatic patients that can last several years after infection. In addition, an animal model of airway disease similar to asthma can be produced with Mycoplasma pulmonis. We hypothesized that patients with chronic, stable asthma would exhibit evidence of mycoplasma in the upper and lower airways. Furthermore, treatment with clarithromycin, a macrolide with known activity against mycoplasma species, would result in improvement in their asthma.