CANCER CACHEXIA

体重减轻预示着癌症患者预后不良。 我们 我假设这种体重减轻是增加休息时间的一个功能， 能量消耗（REE）和厌食症，它是由 白细胞介素-1（IL-1）、白细胞介素-6（IL-6）和肿瘤坏死因子（TNF）。 我们建议通过测量REE，身体成分， 可切除的非小细胞肺癌患者的饮食摄入量和细胞因子水平 在根治性切除之前和之后的细胞癌。 我们建议将这些参数与健康、匹配 对照 此外，我们建议控制抑郁症及其可能的影响， 通过让受试者完成抑郁症问卷来评估这些参数。 最后，我们计划寻找这些细胞因子的存在， 肿瘤本身的免疫组化方法 标本

Weight loss predicts a poor prognosis in the patient with cancer. We hypothesize that this weight loss is a function of increased resting energy expenditure (REE) and anorexia and that it is driven by Interlukin-1 (IL-1), Interlukin-6 (IL-6), and tumor necrosis factor (TNF). We propose to test this hypothesis by measuring REE, body composition, dietary intake, and cytokine levels in patients with resectable non-small cell cancer both before and after curative resection. We propose to compare these parameters to those seen in healthy, matched controls. In addition, we propose to control for depression and its possible effect on these parameters by having subjects complete depression questionnaires. Finally, we plan to look for the presence of these cytokines within the tumor itself by using immunohistochemical methods on resected tumor specimens.