SYSTEMIC PROSTAGLANDIN E1 ON UREA SYNTHESIS/WHOLE BODY NITRGN METAB IN CIRRHOSIS

全身前列腺素 E1 对尿素合成/肝硬化全身氮代谢的影响

• 批准号: 6276574
• 负责人: ELISABETTA BUGIANESI
• 金额: $ 1.83万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276574
• 关键词: aminoacid metabolism; aminoacid transport; clinical research; drug metabolism; drug screening /evaluation; human subject; human therapy evaluation; liver cirrhosis; liver disorder chemotherapy; nitrogen metabolism; pharmacokinetics; prostaglandin E; urea

The aim of this study is to evaluate the metabolic effects of prostaglandin E1 administration in patients with liver cirrhosis and paired healthy controls. The hypotheses being tested are: 1) Prostglandin E1 significantly influences hepatic and whole body amino nitrogen economy in patients with liver cirrhosis; 2) Prostaglandin E1 produces a decrease in urea synthesis, and 3) Prostaglandin E1 might act on the peripheral tissues, through a decreased amino acid efflux, or increased amino-acid uptake and non-oxidative metabolism. To date 4 subjects have been enrolled. No data analysis has been done.

本研究的目的是评估代谢的影响， 前列腺素E1在肝硬化患者中的应用 配对的健康对照。被测试的假设是：1） 前列腺素E1显着影响肝脏和全身氨基 肝硬化患者的氮经济; 2）前列腺素E1 导致尿素合成减少，3）前列腺素E1可能起作用 外周组织，通过减少氨基酸流出，或 增加氨基酸摄取和非氧化代谢。 迄今为止4 受试者已入组。 未进行数据分析。