EFFECT OF SC58635 AT DOSES OF 200/400 MGB BID ON RENAL FUNCTION

200/400 MGB BID 剂量的 SC58635 对肾功能的影响

• 批准号: 6276860
• 负责人: GERALD SCHULMAN
• 金额: $ 3.29万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276860
• 关键词: clinical research; drug interactions; drug screening /evaluation; enzyme inhibitors; glomerular filtration rate; human old age (65+); human subject; kidney function; kidney pharmacology; naproxen; nonsteroidal antiinflammatory agent; pharmacokinetics; prostaglandin endoperoxide synthase; urinalysis

To evaluate the effects of SC-58635 on renal function in healthy, elderly subjects. To assess the effect of SC-58635 on urinary PG in the same population. To compare the effects of SC-58635 at different doses with the effects of naproxen, a COX-1 inhibitor (nonsteroidal anti- inflammatory drug (NSAIDS) on renal inhibitor (nonsteroidal function (glomerular filtration rate) and urinary PG in healthy elderly subjects. To evaluate the safety of SC-58635. To evaluate the pharmacokinetics of SC-58635 in healthy, elderly subjects. This study is complete and a report is forthcoming.

评价SC-58635对健康受试者肾功能的影响， 老年受试者评估SC-58635对尿PG的影响， 同样的人口。比较不同剂量SC-58635的作用 与考克斯-1抑制剂（非甾体抗- 非甾体抗炎药（NSAIDS）对肾抑制剂（非甾体功能 （肾小球滤过率）和尿PG。 评价SC-58635的安全性。评价以下药物的药代动力学 健康老年受试者中的SC-58635。 这项研究已经完成，即将提出报告。