ENERGY EXPENDITURE DURING DEVELOPMENT OF CHILDHOOD OBESITY

儿童肥胖发展过程中的能量消耗

• 批准号: 6277214
• 负责人: RACHEL K JOHNSON
• 金额: $ 2.62万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277214
• 关键词: adipose tissue; adolescence (12-20); bioenergetics; body composition; body physical activity; body water; calorimetry; child physical development; electrical impedance; gene environment interaction; genetic markers; human subject; longitudinal human study; middle childhood (6-11); nutrient intake activity; nutrition related tag; obesity; preschool child (1-5); radionuclide double label

Obesity, which currently affects 25 percent of children, is one of the main causes of pediatric hypertension, and remains a risk factor for non- insulin-dependent diabetes, coronary heart disease and early death when it persists into adulthood. Unfortunately the incidence of obesity in children is increasing despite the fact that our society has become more health and fitness conscious. The aims of this project are: 1. To characterize the pre-obese state with regard to energy expenditure, physical activity and body composition. 2. To identify environmental and phenotypic markers for the development of human obesity. 3. To derive estimates of energy requirements in children based on measurements of energy expenditure, rather than on energy intake data. The project consists of a longitudinal study in children commending at age 4-6 and continuing for a six year period. The following outcome variables are measured in the children; total daily energy expenditure using doubly labeled water, resting energy expenditure using indirect calorimetry, energy expenditure of physical activity, dietary intake, total body water, body fat using DXA and bioelectrical impedance, fat distribution using anthropometrics, and pubertal development using Tanner staging. To date seven children from Vermont have completed the year six protocol. In 1998 an additional seven children are scheduled to complete the protocol.

肥胖症目前影响25％的儿童，是 小儿高血压的主要原因，仍然是非 - 胰岛素依赖性糖尿病，冠心病和早期死亡 持续成年。 不幸的是，肥胖的发生率 尽管我们的社会变得更多，但孩子们仍在增加 健康和健身意识。该项目的目的是：1。 在能量支出方面表征了肥胖状态的状态 体育锻炼和身体成分。 2。确定环境和 表型标志物用于发展人类肥胖症。 3。衍生 根据测量的儿童能量需求的估计 能源消耗，而不是能量摄入数据。项目 由一项在4-6岁以下的儿童进行的纵向研究和 继续六年。 以下结果变量是 在儿童中测量；使用双重的每日能源支出 标记的水，使用间接量热法的静息能量消耗， 体育锻炼，饮食摄入，全身水的能量消耗， 使用DXA和生物电阻抗的体内脂肪，使用的脂肪分布 人类测量法和青春期开发使用Tanner分期。迄今为止 佛蒙特州的七个孩子已经完成了六年级协议。 1998年 安排另外七个孩子来完成协议。