HUMAN CEREBRAL GABA METABOLISM STUDIES IN VIVO WITH MR SPECTROSCOPY

我们建议研究脑谷氨酸和GABA周转。 联合应用促黄体生成素和~(13)C核磁共振成像诊断癫痫。对两部小说的回应 抗癫痫药物将作为阐明代谢的探针 对GABA水平升高的反应。 我们继续研究体内GABA比率与 谷氨酸和脱羧酶(GAD)的合成、活性及GABA 集中精神。评估增加的人脑GABA对 苯二氮卓类受体作为GABA-A受体标志物的表达 使用连续单光子发射计算机断层扫描(SPECT)和1H 核磁共振波谱(1H NMRS)。探索其作用机制 加巴喷丁对人脑GABA含量的影响 用连续测量方法给药的脑组织比率 谷氨酸、氨基丁酸和谷氨酰胺的周转 加巴喷丁的管理。

We propose to study brain glutamate and GABA turnover inpatients with epilepsy using combined lH and 13C NMRS. The responses to two novel anti-epileptic drugs will serve as probes to clarify the metabolic response to increased levels of GABA. We continue to investigate the relationship between in vivo rate of GABA synthesis, glutamic acid and decarboxylase (GAD) activity , and GABA concentration. Assess the effects of increased Human Brain GABA on the expression of Benzodiazepine receptors as a marker for GABA-A receptors using serial single photon emission computer tomography (SPECT) and 1H Magnetic Resonance Spectroscopy (1H NMRS). Explore the mechanisms associated with the increase in human brain GABA following Gabapentin administration using serial measurements of the rate of cerebral glutamate, GABA, and glutamine turnover before and after the administration of Gabapentin.