SNX-111 鞘内给予 PT 的开放标签剂量递增研究-猫眼课题宝

SNX-111 鞘内给予 PT 的开放标签剂量递增研究

批准号：

6278178

负责人：

VALERIE C ANDERSON

金额：

$2.86万

依托单位：

OREGON HEALTH & SCIENCE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1997

资助国家：

美国

项目状态：

已结题

起止时间：

1997-12-01 至 1998-11-30

来源：

https://reporter.nih.gov/project-details/6278178

关键词：

calcium channel blockers chronic pain clinical research clinical trials drug delivery systems drug screening /evaluation human subject human therapy evaluation nervous system disorder chemotherapy

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英文摘要

SNX-111 is a voltage-sensitive calcium channel blocker that specifically blocks neuronal (N-type) calcium channels. These channels are found in highest density within the substantia gelatinosa of the dorsal horn, where blockade of calcium influx has been shown to produce analgesia. The present study is designed to evaluate the safety and efficacy of low dose, intrathecal SNX-111 in relieving chronic, nonmalignant pain. Drug will be delivered via implanted intrathecal infusion system. Dose will be titrated weekly over 7 weeks until analgesia is achieved or until intolerable side effects occur.

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