T CELL RESPONSE CHARACTERIZATION IN HEPATITIS C

丙型肝炎中的 T 细胞反应特征

• 批准号: 6278768
• 负责人: Dwain Louis Thiele
• 金额: $ 2.47万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278768
• 关键词: T lymphocyte; acute disease /disorder; antibody formation; cellular immunity; clinical research; hepatitis C; hepatitis C virus; human subject; virus antigen; virus infection mechanism

When initiated in 1990, the specific aims of this project were to assess the T cell proliferative response to hepatitis C antigens during the course of acute hepatitis C virus (HCV) infection and determine whether specific patterns or levels of T cell responses correlated with disease outcome. This objective was based on the hypothesis that in the course of hepatitis C infection, as previously observed during hepatitis B infection, the development of T cell responses to specific viral proteins would closely correlate with resolution of acute viral hepatitis and clearance of viral infection. As understanding the nature of hepatitis C infection and liver disease has grown over the past 7 years these specific aims have been modified to encompass broader attempts to follow antibody responses to various hepatitis antigens during the evolution of hepatitis C infection and to characterize the nature of acute hepatitis cases previously classified as acute non-A, non-B hepatitis.

该项目于1990年启动时，其具体目标是评估 丙型肝炎病毒感染期间T细胞对丙型肝炎抗原的增殖反应 急性丙型肝炎病毒（HCV）感染的过程，并确定是否 与疾病相关的T细胞反应的特定模式或水平 结果。 这一目标是基于这样的假设，即在课程中， 丙型肝炎感染，如以前观察到的B型肝炎 感染，T细胞对特定病毒的反应的发展 蛋白质将与急性病毒感染的消退密切相关。 肝炎和清除病毒感染。 随着对自然的了解 丙型肝炎感染和肝脏疾病的发病率在过去7年中有所上升 多年来，这些具体目标已被修改，以涵盖更广泛的 试图跟踪对各种肝炎抗原的抗体应答 丙型肝炎病毒感染的演变过程中， 急性肝炎个案的性质以往分类为急性非甲类， 非乙型肝炎