T CELL RESPONSE CHARACTERIZATION IN HEPATITIS C

在1990年启动时，该项目的具体目标是评估 丙型肝炎患者外周血中T细胞的增殖反应 急性丙型肝炎病毒(丙型肝炎病毒)的感染过程并确定 与疾病相关的T细胞反应的特定模式或水平 结果。这一目标是基于这样的假设，即在课程中 丙型肝炎感染，就像之前在乙肝期间观察到的那样 感染，发展T细胞对特定病毒的反应 蛋白质将与急性病毒的解决密切相关 肝炎和清除病毒感染。就像理解自然 在过去的7年里，丙型肝炎感染和肝病的比例有所上升 多年来，这些具体目标已被修改，以涵盖更广泛的内容 尝试跟踪对各种肝炎抗原的抗体反应 在丙型肝炎感染的演变过程中，并表征 以前被列为急性非甲型肝炎的急性肝炎病例的性质， 非乙型肝炎。

When initiated in 1990, the specific aims of this project were to assess the T cell proliferative response to hepatitis C antigens during the course of acute hepatitis C virus (HCV) infection and determine whether specific patterns or levels of T cell responses correlated with disease outcome. This objective was based on the hypothesis that in the course of hepatitis C infection, as previously observed during hepatitis B infection, the development of T cell responses to specific viral proteins would closely correlate with resolution of acute viral hepatitis and clearance of viral infection. As understanding the nature of hepatitis C infection and liver disease has grown over the past 7 years these specific aims have been modified to encompass broader attempts to follow antibody responses to various hepatitis antigens during the evolution of hepatitis C infection and to characterize the nature of acute hepatitis cases previously classified as acute non-A, non-B hepatitis.