氟氢可的松对等容量血液透析患者血压的影响-猫眼课题宝

氟氢可的松对等容量血液透析患者血压的影响

批准号：

6278273

负责人：

THOMAS H HOSTETTER

金额：

$3.69万

依托单位：

UNIVERSITY OF MINNESOTA

依托单位国家：

美国

项目类别：

财政年份：

1997

资助国家：

美国

项目状态：

已结题

起止时间：

1997-12-01 至 1998-11-30

来源：

https://reporter.nih.gov/project-details/6278273

关键词：

angiotensin /renin /aldosterone hypertension blood pressure clinical research clinical trials corticosteroid analog drug adverse effect hemodialysis human subject human therapy evaluation kidney disorder chemotherapy kidney pharmacology medical complication

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英文摘要

Protocol 533 addresses the mechanism involved in generating hypertension by mineralocorticoids. The most commonly accepted mechanism is that mineralocorticoids cause hypertension through salt retention and subsequent volume expansion. This study addresses another possibility, namely, direct vascular effects of aldosterone that are independent of volume retention. This is achieved by keeping dialysis patients at the same weight while receiving fludrocortisone.

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