STUDY OF PLATINUM COMPOUND AND PACLITAXEL IN EPITHELIAL OVARIAN CARCINOMA

铂化合物与紫杉醇治疗上皮性卵巢癌的研究

• 批准号: 6279586
• 负责人: JONATHAN S BEREK
• 金额: $ 1.77万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279586
• 关键词: antineoplastics; carboplatin; cis platinum compound; clinical research; combination chemotherapy; drug adverse effect; drug screening /evaluation; female; human subject; human therapy evaluation; neoplasm /cancer chemotherapy; neoplasm /cancer classification /staging; neoplasm /cancer relapse /recurrence; ovary neoplasms

The specific aims of this study are to compare recurrence-free interval and survival in patients with optimal (<1 cm residual) stage III epthelial ovarian cancer treated with two different treatment regiments of cisplatin/carboplatin and paclitaxel; compare toxicity and complications of two different regimens for administering cisplatin/carboplatin and paclitaxel in patients with optimal (<1 cm residual) stage III epithelial ovarian cancer; and correlate serial measurements of serum CA-125 levels with recurrence-free interval.

本研究的具体目的是比较无复发间期 最佳（<1 cm残留）III期患者的生存率 两种不同治疗方案治疗的上皮性卵巢癌 顺铂/卡铂和紫杉醇;比较毒性和 两种不同给药方案的并发症 顺铂/卡铂和紫杉醇在最佳（<1 cm）患者中的应用 残留）III期上皮性卵巢癌;和相关系列 测量血清CA-125水平和无复发间隔。