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PHASE II TRIAL OF 9-CIS RETINOIC ACID (ALRT 1057) IN AIDS-KS (AMC PROT.002)

PHASE II TRIAL OF 9-CIS RETINOIC ACID (ALRT 1057) IN AIDS-KS (AMC PROT.002)
9-CIS 视黄酸 (ALRT 1057) 在 AIDS-KS (AMC PROT.002) 中的 II 期试验
批准号：
6279641
负责人：
STEVEN MILES
金额：
$1.77万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6279641
关键词：
AIDS therapy HIV infections Kaposi's sarcoma antineoplastics clinical research cytotoxicity dosage drug adverse effect drug screening /evaluation human immunodeficiency virus human subject human therapy evaluation neoplasm /cancer chemotherapy neoplastic growth opportunistic infections retinoate

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中文摘要
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英文摘要
Kaposi's sarcoma (KS) is a type of cancer that is related to my infection with the human immunodeficiency virus (HIV). The only treament that consistently causes the tumor to shrink in all patients is the use of cancer chemotherapy drugs and interferons. Recent laboratory studies suggest that a new vitamin A -like chemical, 9-cis- RA(ALRT1057) can slow the growth of this type of cancer cells in the laboratory. This drug has significant side effects. This research study will give increasing doses of 9-cis-RA to determine the safety and toxic side effects.
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PHASE II TRIAL OF 9-CIS RETINOIC ACID (ALRT 1057) IN AIDS-KS (AMC PROT.002)
DOSE ESCALATING STUDY OF CUTANEOUS AIDS RELATED KAPOSI'S SARCOMA
STEM CELL MOBILIZATION AND HARVESTING FROM THE PERIPHERAL BLOOD
PHASE I,DOOUBLE-BLINDED TRIAL OF RECOMBINANT HUMAN IL-12 IN HIV INFECTED PTS
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