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EFFECT OF RILUZOLE ON LEVELS OF BRAIN LACTATE IN PATIENT WITH HUNTINGTON'S DIS

EFFECT OF RILUZOLE ON LEVELS OF BRAIN LACTATE IN PATIENT WITH HUNTINGTON'S DIS
利鲁唑对亨廷顿舞蹈症患者脑乳酸水平的影响
批准号：
6280034
负责人：
Walter J. Koroshetz
金额：
$2.74万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6280034
关键词：
Huntington's disease amyotrophic lateral sclerosis brain metabolism clinical research clinical trial phase I drug administration rate /duration drug screening /evaluation human subject human therapy evaluation lactates magnetic resonance imaging mental disorder chemotherapy nervous system disorder chemotherapy thiazide

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This protocol is a pilot study that will investigate the use of riluzole in patients with Huntington's Disease (HD). Riluzole has shown promise in the treatment of amyotrophic lateral sclerosis, another neuro- degernative disorder. The investigators will administer riluzole to 8 subjects with HD for 6 weeks as an open-label study. The study endpoint will include changes in brain lactate levels as measured by MR spectroscopy following administration of the study drug and four weeks after stopping medication.
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