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SEARCH FOR THE IDDM GENES WITHIN THE HLA REGION IN AFRICAN AMERICANS

SEARCH FOR THE IDDM GENES WITHIN THE HLA REGION IN AFRICAN AMERICANS
在非裔美国人的 HLA 区域寻找 IDDM 基因
批准号：
6280835
负责人：
HENRY A ERLICH
金额：
$2.39万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6280835
关键词：
clinical research diabetes mellitus genetics family genetics genetic susceptibility human subject insulin dependent diabetes mellitus major histocompatibility complex

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英文摘要
Very few studies have typed HLA of African-Americans with diabetes, and predisposing alleles common in this population remain largely unknown. Almost no literature exists on this subject, and yet an understanding of susceptibility specific to the African-American population is essential in identifying at-risk African-American children. Furthermore, the unusual form of diabetes (type 1.5) seen in African Americans, in which patients present in ketoacidosis, but subsequently do not require insulin, may have a unique HLA type. Identification of this type could be used to counsel families.
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