CHARACTERIZATION OF CARBORANE CONTAINING POLYPEPTIDES

我们已经合成了邻位碳硼烷氨基酸，并计划 描述其插入的结构效应 均聚氨基酸，例如聚丙氨酸或聚苯丙氨酸。 的 这些肽的二级结构应该是螺旋状的， 由于空间效应，受到碳硼烷的扰动。 与...比较 其它β-氨基酸插入如邻氨基苯甲酸 这些肽将使我们能够表征特定的螺旋断裂 碳硼烷的相互作用。 螺旋结构的改变导致了 通过插入这些类型的氨基酸， 使用圆二色性光谱然后通过2-D NMR测定。 使用MidasPlus建模将使我们能够预测 修饰的多肽，并将帮助我们选择有用的模型 化合物进行进一步研究。

We have synthesize and ortho-carborane amino acid and plan to characterize the structural effects of its insertion into homopolyaminoacids such as poly-Alanine or poly-Phenylalanine. The secondary structure of these peptides should be helical, with perturbation by the carborane due to steric effects. Compaison with other beta-amino acid insertions such as ortho-aminobenzoic acid in these peptides will allow us to characterize specific helix-breaking interactions of the carborane. The change in helical structure caused by insertions of these types of amino acids will be initially determined using circular dichroism spectroscopy then by 2-D NMR. Modeling using MidasPlus will allow us to predict the structure of the modified polypeptides, and will aid us in selecting useful model compounds for further studies.