OPTICAL PROPERTIES OF BIO TISSUES W/ STUDY USING FREQ DOMAIN PHOTON MIGRATION

使用频域光子迁移研究生物组织的光学特性

• 批准号: 6280337
• 负责人: CHRISTIAN DEPEURSINGE
• 金额: $ 0.26万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280337
• 关键词: biomedical resource; lasers; model design /development; technology /technique

Laser Microbeam and Medical Program (LAMMP) facilities provide access to a multi-frequency, Frequency-Domain Photon Migration (FDPM) system which has proven its ability to extract optical properties, scattering and absorption, from a single-distance measurement on tissue-like phantoms and in vivo on human tissues. We, at EPFL (Dr. Depeursinge's group), have developed a Spatially-Resolved Photon Migration (SRPM) probe which allows local optical property measurements of biological tissues. Our current data analysis procedure is based upon comparisons of measurements to results of Monte Carlo numerical simulations. We propose to conduct combined experimental studies, using the LAMMP FDPM apparatus and clinical resources, to define an optimal photon migration system capable of deriving accurately the optical properties of complex, inhomogeneous tissues. This study involves 1) a quantitative determination of the volume of tissue interrogated in each technique; 2) an experi mental study on tissue-like layered solid phantoms in order to assess our ability to optically characterize each layer independently by using our combined setup; 3) the design of an optimal system (probe + inversion model) according to a thorough analysis of the potential advantages of frequency modulation at short distances (<J5Jmm); 4) clinical trials on breast, brain and gynecological human tissues, in vivo. We believe that LAMMP is able to provide us with a unique set of experimental and clinical facilities, which is optimal to complete the long-term goal of our research in this field, i.e. in vivo optical characterization of tissues as an aid to diagnostics and imaging. The outcome of this study and our experience in using LAMMP FDPM instrumentation will benefit our research efforts in photon migration and our contribution in the European Union-sponsored program Biomed-Near InfraRed Spectroscopy and Imaging (NIRSI).

激光微束和医疗计划（LAMMP）设施提供 访问多频频域光子迁移（FDPM） 该系统已经证明了其提取光学特性的能力， 散射和吸收，从单距离测量 组织样体模和体内人体组织。 我们在EPFL（博士。 Depeursinge的小组），开发了一种空间分辨光子 迁移（SRPM）探头，允许局部光学特性 生物组织的测量。 我们目前的数据分析 该程序基于测量结果与 蒙特卡罗数值模拟。 我们建议进行合并 实验研究，使用LAMMP FDPM设备和临床 资源，以定义最佳光子迁移系统， 精确地推导出复杂的、非均匀的 组织中 本研究涉及1）定量测定 每种技术中询问的组织体积; 2）实验 研究组织状分层实体模型，以评估我们 能够通过使用光学特性独立地表征每层 我们的组合设置; 3）最佳系统的设计（探头+ 反演模型），根据对潜在的 短距离（<J5 Jmm）调频的优点; 4） 乳腺、脑和妇科人体组织的临床试验， vivo. 我们相信LAMMP能够为我们提供一套独特的 实验和临床设施，这是最佳的完成 我们在这一领域的研究的长期目标，即在体内光学 组织表征作为诊断和成像的辅助手段。 的 本研究的结果和我们使用LAMMP FDPM的经验 仪器将有利于我们在光子迁移方面的研究工作 以及我们在欧盟赞助的项目中的贡献 生物医学近红外光谱和成像（NIRSI）。