MODELING BEHAVIORAL OUTCOMES IN FRAGILE X GIRLS

对脆弱 X 女孩的行为结果进行建模

• 批准号: 6121790
• 负责人: DEBORAH VALULICK DAWSON
• 金额: $ 0.7万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121790
• 关键词: biomedical resource; child (0-11); female; genetics; mental disorders; psychology; statistics /biometry

A series of behavioral checklists, administered to the parent, were used to characterize young girls with Fragile X Syndrome as well as a comparison group of developmentally delayed girls known to test negative for Fragile X. These included the Conners and Autism Checklists. The purpose of this project is to assess the relationship of the behavioral dimensions measured through these instruments, particularly hyperactivity and autism measures, with age and IQ, and to compare these relationships for the two groups. Results to date indicate a nonlinear relationship between age and IQ status, suggesting potential, nonadditive, effects of developmental stage and severity. Current efforts are focusing in characterizing these relationships through traditional regression modeling, classification and regression trees, and neural network approaches. Future efforts will include the development of predictive models for potential use in screening to identify individuals likely to have Fragile X Syndrome in developmentally delayed populations, with the aim of identifying candidates for DNA testing.

一系列行为核对表，发给父母， 也被用来描述患有脆性X综合征的年轻女孩 作为一组发育迟缓的女孩进行测试 脆性X阴性。这些包括康纳斯和自闭症 核对表。这个项目的目的是评估两国关系 通过这些工具测量的行为维度， 特别是多动症和自闭症的测量，与年龄和智商，以及 以比较两组的这些关系。迄今为止的结果 表明年龄和智商状态之间存在非线性关系， 暗示潜在的、非相加的、发育阶段和 严肃性。目前的工作重点是描述这些 关系通过传统的回归建模、分类 回归树和神经网络方法。未来的努力 将包括开发预测模型，以潜在地用于 筛查可能患有脆性X综合征的个体 发育迟缓的人群，目的是识别 DNA测试的候选人。