EPR OF METHEMOGLOBIN FORMATION IN RED CELLS W/ UNSTABLE HEMOGLOBIN

不稳定血红蛋白红细胞中高铁血红蛋白形成的 EPR

• 批准号: 6281735
• 负责人: ODED SHAKA
• 金额: $ 3.74万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-05 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281735
• 关键词: bioengineering /biomedical engineering; biological products; biomaterials; biomedical equipment development; biomedical resource; technology /technique

Heterozygous as well as homozygous containing hemoglobin S (HbS) red cells contain higher concentrations of methemoglobin than those not containing the mutant protein. Conditions have been developed for low temperature investigations of red cells that have been incubated 37x. Oxidized hemoglobin concentrations (S = 5/2 and g imid for S = 1/2) are related to catalase levels and correlated with hematocrit of samples under investigation. Comparisons are made with normal red cells. It was found that HbS-containing cells have higher concentrations of oxidized hemoglobin than normals.

杂合子和纯合子含血红蛋白S （HbS）