ANIMAL RESOURCE IMPROVEMENT AT THE MGH

要求提供资金，以扩大和改善动物的住房和支持 马萨诸塞州总医院的设施。一个关键的需求是 确定提供屏障设施以安置嵌合啮齿动物 （小鼠）使用基因置换（敲除）技术产生，和 传统的转基因小鼠。屏障空间通过以下方式提供 机构资金。需要资金来适当装备这些设施。 这些资金将用于购买更多的微型隔离器， 啮齿动物架，并更换损坏的微型隔离器住房单位， 不符合《指南》标准的工作台。“那 实验性移植计划取得了成功， 需要重定向和扩展程序以包括第二个 非人灵长类物种（狒狒）用于异种研究。适当 狒狒的笼舍不可用，必须按顺序获得 让我们可以用大狒狒继续研究。MGH动物资源 1991年，在611，903美元的援助下， 改善动物资源。整个项目约为 三百四十万MGH动物资源计划随后获得认证 1993年7月获得AAALAC的认可，并于7月获得继续认证。 1996.医院的动物资源计划继续下去是很重要的 遵守适用的政策和法规， 保持AAALAC认证。该提案的批准和资助是 如果MGH要实现这一目标并响应 非常成功的研究项目

Funds are requested to expand and improve the animal housing and support facilities at the Massachusetts General Hospital. A critical need has been identified to provide for barrier facilities to house chimeric rodents (mice) produced using Gene Replacement (Knockout) Technology and traditional transgenic mice. The barrier space has been provided through institutional funds. Funds are needed to properly equip these facilities. These funds will be used to purchase additional micro-isolator units and rodent racks, and replace deteriorated micro-isolator housing units and workbenches which do not meet the standards of the "Guide." The experimental transplantation program has experienced successes which require a redirection and expansion of the program to include a second non-human primate species (baboon) for xenographic studies. Appropriate cages for housing baboons are not available and must be obtained in order to allow continued research using large baboons. The MGH Animal Resource Facilities were initially renovated in 1991, with the aid of a $611, 903 Animal Resource Improvement grant. The total project was approximately $3.4 million. The MGH Animal Resource Program was subsequently accredited by AAALAC in July 1993, and continued accreditation was awarded in July 1996. It is important that the Hospital's animal resource program continue in compliance with applicable policies and regulations and that it maintain AAALAC accreditation. Approval and funding of this proposal is essential if MGH is to accomplish this goal and be responsive to the extremely successful research programs at this institution.