NEW APPROACHES TO CROSS SECTIONAL STUDIES OF ASTHMA

哮喘横断面研究的新方法

• 批准号: 2863610
• 负责人: CHRISTINA A HOLCROFT
• 金额: $ 5.38万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2863610
• 关键词: asthma; data collection methodology /evaluation; employee; evaluation /testing; fluid; human subject; mathematical model; metals; occupational disease /disorder; occupational hazard; occupational health /safety; questionnaires; respiratory disorder epidemiology; respiratory function; spirometry; statistics /biometry

DESCRIPTION: (Adapted from the Investigator's Abstract) In this SERCA proposal, the principal investigator, a biostatistician, will work with an established team of researchers in epidemiology, occupational medicine, and industrial hygiene, to develop and refine study methods to deal with selection biases that have severely limited our ability to accurately study asthma in the workplace. A previous cross-sectional study of metalworking fluids (MWF) and asthma suffered from well documented biases due to the healthy worker effect (HWE) and sparse information about the pattern of asthma since employment. However, the MWF-asthma link is well enough established by clinical evidence to merit further examination of the exposure-response relationship. To address shortcomings in the earlier study, the cross-sectional sample will be expanded by adding previously excluded females, additional blacks, and new hires to from a new cohort of 3000 autoworkers; and time specific information about asthmatic events - both initial onset of disease as well as exacerbation - will be collected by a mailed questionnaire. The analysis will account for job transfer bias by using time windows to redefine exposure in a more biologically relevant manner and will apply a Cox proportional hazards model to estimate risk in both the cross-section and the cohort. The new methods developed for data collection and analysis will provide the research experience necessary to establish the investigator's career in the occupational health field, improve techniques for studying asthma in cross-sectional studies of working populations, and further our understanding of the relationship between asthma and MWF.

描述：（改编自研究者摘要）在本SERCA中 建议，主要研究者，一名生物统计学家，将与一名 建立了流行病学、职业医学和 工业卫生，制定和完善研究方法，以应对 选择偏差严重限制了我们准确研究 工作场所的哮喘 以前的金属加工横截面研究 液体（MWF）和哮喘遭受了有据可查的偏见， 健康工人效应（HWE）和稀疏信息的模式， 工作以来的哮喘 然而，MWF与哮喘之间的联系已经足够好了， 通过临床证据确定，值得进一步检查 反应关系。 为了解决以前的缺点， 研究中，横截面样本将通过增加以前的 排除女性，额外的黑人和新员工，从一个新的队列， 3000名汽车工人;以及关于哮喘事件的特定时间信息- 疾病的初始发作以及加重-将由以下人员收集 一份邮寄的问卷 该分析将通过以下方式解释工作转移偏见： 使用时间窗来重新定义暴露， 并将应用考克斯比例风险模型来估计 无论是横截面还是队列。 为数据开发的新方法 收集和分析将提供必要的研究经验， 在职业健康领域建立调查员的职业生涯， 在工作人员横断面研究中研究哮喘改进技术 人口，并进一步了解我们之间的关系， 哮喘和MWF。