BEHAVIORAL PHARMACOLOGY OF OPIOIDS

阿片类药物的行为药理学

• 批准号: 2654337
• 负责人: CHARLES P FRANCE
• 金额: $ 8.1万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-10 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2654337
• 关键词: Macaca mulatta; analgesia; buprenorphine; drug abuse chemotherapy; drug addiction; drug addiction antagonist; drug administration rate /duration; drug interactions; drug screening /evaluation; drug withdrawal; fentanyl; gastrointestinal pharmacology; guinea pigs; immunopharmacology; laboratory mouse; methadone; morphine; naltrexone; nonhuman therapy evaluation; opiate alkaloid; opioid receptor; pigeons; psychopharmacology; reproductive system pharmacology; respiratory pharmacology

This application describes a request for an ADAMHA Research Scientist Development Award for Dr. Charles P. France. The Department of Pharmacology at LSU Medical Center has a strong and growing research effort in ares of drug abuse and I will use the support provided by an RSDA to expand our overall drug abuse research program. Specifically, this request is an attempt to provide reliable salary support for me so that I can increase my research efforts in drug abuse, compete for additional extramural funds to support drug abuse research in my laboratory, and maintain an laboratory environment conducive to the training of young researchers in the behavioral pharmacology of drug abuse. My current formal teaching requirements as well as committee assignments will be reduced in the event this application is awarded. The primary areas of research supported by this application involve the use of drug discrimination procedures to study opioid dependence and withdrawal in nonhuman species. This research attempts to characterize important behavioral and pharmacological features of opioid dependence as well as identify novel compounds that might be effective in the treatment of opioid abuse. Moreover, receptor theory will be applied extensively to discrimination and other behavioral procedures both to test the utility of this approach and to characterize drug affinity, selectivity and efficacy in vivo. Other procedures that will be used in concert with drug discrimination procedures include analgesia studies in monkeys and mice, self-administration studies in rodents and monkeys, and studies in the electrically-stimulated mouse vas deferens. In addition, I will continue to pursue collaborative research on the immunologic effects of opioids in monkeys and in mice as well as studies on the importance of metabolic factors in the behavioral pharmacology of drugs of abuse. The RSDA will allow me to take advantage of the expertise of my current collaborators, particularly those with more molecular approaches. A continued and more extensive interaction with these scientists will increase my knowledge of various areas within pharmacology that are important to drug abuse in general.

此申请描述了对ADAMHA研究科学家的申请 查尔斯·P·法兰西博士发展奖。美国商务部 路易斯安那州立大学医学中心的药理学研究力度很大，而且还在不断增长 在药物滥用方面，我将利用RSDA提供的支持来 扩大我们的整体药物滥用研究项目。具体地说，这个请求 是试图为我提供可靠的工资支持，这样我就可以 加大对药物滥用的研究力度，争取更多 用于支持我实验室的药物滥用研究的外部资金，以及 维护有利于培养年轻人才的实验室环境 研究药物滥用的行为药理学的研究人员。我目前的情况 正式的教学要求以及委员会作业将会是 在此申请被授予的情况下减少。的主要领域 这项申请支持的研究涉及药物的使用 研究阿片类药物依赖和戒断的歧视程序 非人类物种。这项研究试图将重要的 阿片类药物依赖的行为和药理学特征 确定可能有效治疗阿片类药物的新化合物 虐待。此外，受体理论将被广泛应用于 辨别和其他行为程序都是为了测试 这种方法并表征药物的亲和力、选择性和有效性 在活体内。其他将与药物一起使用的程序 辨别程序包括在猴子和老鼠身上进行的止痛研究， 啮齿动物和猴子的自我管理研究，以及 电刺激小鼠输精管。另外，我还会继续 开展阿片类药物免疫学效应的合作研究 猴子和小鼠体内以及代谢的重要性的研究 滥用药物行为药理学的影响因素。RSDA将 请允许我利用我现在的合作者的专业知识， 尤其是那些拥有更多分子方法的人。一个持续的、更多的 与这些科学家的广泛互动将增加我对 药理学中对药物滥用很重要的各个领域 将军。