BRAIN METABOLISM IN ALCOHOLICS WITH/WITHOUT CHALLENGE WITH BENZODIAZEPINE DRUG
有/没有苯二氮卓类药物挑战的酗酒者的大脑代谢
基本信息
- 批准号:6283038
- 负责人:
- 金额:$ 2.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-06-04 至 1998-11-30
- 项目状态:已结题
- 来源:
- 关键词:alcoholism /alcohol abuse benzodiazepine receptor brain metabolism clinical research drug withdrawal gamma aminobutyrate glucose metabolism human subject lorazepam magnetic resonance imaging neural inhibition neural transmission neurochemistry neuropharmacology neuropsychological tests positron emission tomography psychopharmacology
项目摘要
The devastating social, medical, and economic effects of alcoholism have
intensified the need to understand the neurochemical mechanisms underlying
alcohol self administration and dependence. Studies in animals and in
vitro systems have produced increasing evidence that the GABA-
benzodiazepine receptor complex (GBRC) mediates some of the
pharmacological and behavioral effects of ethanol, especially the genetic
variability in ethanol response. Furthermore, recent studies from our
laboratory in which we have used PET to directly examine regional brain
glucose metabolism in the brains of normal male subjects and recently
detoxified male alcoholics (Volkow et al. 1993) support the involvement of
the GBRC as a neurochemical substrate in alcoholism.
Purpose:
Specific aim 1 To investigate the activity of GBRC mediated inhibitory
neurotransmission in normal controls and recently detoxified alcoholics;
Specific aim 2 To examine the influence of the time period of alcohol
withdrawal on GBRC mediated inhibitory neurotransmission;
Specific aim 3 To examine the influence of the time period of alcohol
withdrawal on regional brain glucose metabolism during baseline.
酗酒对社会、医疗和经济的破坏性影响,
更需要了解潜在的神经化学机制
酒精自我管理和依赖。在动物和
体外系统已经产生了越来越多的证据表明,GABA-
苯二氮卓受体复合物(GBRC)介导的一些
乙醇的药理学和行为学效应,尤其是遗传学效应,
乙醇响应的可变性。此外,我们最近的研究表明,
我们在实验室中使用PET直接检查局部大脑
正常男性受试者大脑中的葡萄糖代谢,
解毒的男性酗酒者(Escherow等人,1993年)支持参与
GBRC作为酒精中毒的神经化学底物。
目的:
具体目的:1.研究GBRC介导的抑制
正常对照组和最近戒毒的酗酒者的神经传递;
具体目标2:研究饮酒时间的影响
戒断对GBRC介导的抑制性神经传递的影响;
具体目标3研究饮酒时间段的影响
在基线期间对局部脑葡萄糖代谢的影响。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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NORA D VOLKOW其他文献
NORA D VOLKOW的其他文献
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{{ truncateString('NORA D VOLKOW', 18)}}的其他基金
MEASUREMENT OF BRAIN METABOLISM AND BRAIN DOPAMINE CONCENTRATION WITH FLUORINE
用氟测量脑代谢和脑多巴胺浓度
- 批准号:
7375388 - 财政年份:2005
- 资助金额:
$ 2.44万 - 项目类别:
METHAMPHETAMINE EFFECTS IN BRAIN DOPAMINE ACTIVITY
甲基苯丙胺对大脑多巴胺活动的影响
- 批准号:
7203618 - 财政年份:2004
- 资助金额:
$ 2.44万 - 项目类别:
Measurement of Brain Metabolism and Brain dopamine concentration with Fluorine
用氟测量脑代谢和脑多巴胺浓度
- 批准号:
7044297 - 财政年份:2003
- 资助金额:
$ 2.44万 - 项目类别:
PET STUDIES OF BRAIN DOPAMINE IN COCAINE ABUSERS
可卡因滥用者大脑多巴胺的 PET 研究
- 批准号:
6283039 - 财政年份:1998
- 资助金额:
$ 2.44万 - 项目类别:
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