GRAM-NEGATIVE INFECTION AND AIRWAY INFLAMMATION

口腔和呼吸道分泌物的改变可能会促进 细菌和中性粒细胞上皮粘附分子导致气道 损伤、炎症和肺部深部感染。 A.具体目标 1.建立革兰阴性杆菌感染的人体模型。 2.确定确定殖民化路径的变量，以降低 呼吸道感染 3.区分感染性和非感染性炎症途径 在人类疾病中。

Alterations in oral and respiratory secretions may promote increases in bacterial and neutrophil epithelial adhesion molecules leading to airway injury, inflammation and deep lung infection. A. SPECIFIC AIMS 1. To establish a human model of gram-negative infection. 2. To identify variables that define the path of colonization to lower respiratory tract infection. 3. To differentiate infectious from non-infectious inflammatory pathways in human disease.