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FACTOR V LEIDEN PATIENTS WITH CORONARY ARTERY VEIN GRAFT OCCLUSION

FACTOR V LEIDEN PATIENTS WITH CORONARY ARTERY VEIN GRAFT OCCLUSION
冠状动脉静脉移植物闭塞的 V 因子 LEIDEN 患者
批准号：
6282780
负责人：
DAVID McLeod HERRINGTON
金额：
$3.63万
依托单位：
WAKE FOREST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6282780
关键词：
blood vessel transplantation cardiovascular disorder epidemiology clinical research coagulation factor V gene mutation human subject medical complication transplant rejection vein occlusion venous thrombosis

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中文摘要
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英文摘要
Based on the primary hypothesis that prevalence of the Factor V Leiden mutation will be higher in patients with vein graft occlusions than in those without, this pilot study seeks to estimate the prevalence of the mutation in 100 patients w/ 100 patients without angiographically proven vein graft occlusion. The presence of the mutation is strongly associated w/ deep venous but not arterial thrombotic events. If the association can be established with greater risk of veingraft failure, an argument could be made to avoid vein grafts in pts w/ the mutation.
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