FACTOR V LEIDEN PATIENTS WITH CORONARY ARTERY VEIN GRAFT OCCLUSION

冠状动脉静脉移植物闭塞的 V 因子 LEIDEN 患者

• 批准号: 6282780
• 负责人: DAVID McLeod HERRINGTON
• 金额: $ 3.63万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282780
• 关键词: blood vessel transplantation; cardiovascular disorder epidemiology; clinical research; coagulation factor V; gene mutation; human subject; medical complication; transplant rejection; vein occlusion; venous thrombosis

Based on the primary hypothesis that prevalence of the Factor V Leiden mutation will be higher in patients with vein graft occlusions than in those without, this pilot study seeks to estimate the prevalence of the mutation in 100 patients w/ 100 patients without angiographically proven vein graft occlusion. The presence of the mutation is strongly associated w/ deep venous but not arterial thrombotic events. If the association can be established with greater risk of veingraft failure, an argument could be made to avoid vein grafts in pts w/ the mutation.

基于因子V莱顿流行的基本假设 静脉移植物闭塞患者的突变将高于 那些没有，这项初步研究试图估计的患病率 100例未经血管造影证实的患者的突变 静脉移植物闭塞。突变的存在与此密切相关。 W/深静脉血栓事件，而不是动脉血栓事件。如果该协会可以 如果被证明有更大的失败风险，一个论点可能是 用来避免带有突变的PTS中的静脉移植。