FLUORESCENT TWO PHOTON ABSORBING MOLECULES

荧光两个光子吸收分子

• 批准号: 6188809
• 负责人: SETH R MARDER
• 金额: $ 20.53万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6188809
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biotin; chemical structure function; chemical synthesis; chromophore; fluorescence; fluorescence microscopy; fluorescent dye /probe; hydropathy; ionophores; technology /technique development

DESCRIPTION (Adapted from abstract): The project is aimed at understanding how to enhance two-photon absorption cross-sections of organic molecules to develop two-photon fluorophores. This could greatly enhance the applicability of two-photon fluorescence scanning microscopy (TPFSM). Guidelines for the synthesis of suitable molecules include high two-photon absorption cross section, high fluorescence quantum yield, tunable hydrophilicity, incorporation of functional groups for selective labeling, and photochemical stability to prevent rapid bleaching under laser irradiation.

描述（改编自摘要）：该项目旨在了解如何 提高有机分子的双光子吸收截面， 双光子荧光团。这可以大大提高 双光子荧光扫描显微镜（TPFSM）。准则 合适分子的合成包括高双光子吸收交叉 切片，高荧光量子产率，可调亲水性，掺入 用于选择性标记的官能团，以及光化学稳定性， 防止在激光照射下快速漂白。