荧光两个光子吸收分子-猫眼课题宝

荧光两个光子吸收分子

批准号：

6188809

负责人：

SETH R MARDER

金额：

$20.53万

依托单位：

UNIVERSITY OF ARIZONA

依托单位国家：

美国

项目类别：

财政年份：

1999

资助国家：

美国

项目状态：

已结题

起止时间：

1999-08-01 至 2002-07-31

来源：

https://reporter.nih.gov/project-details/6188809

关键词：

bioengineering /biomedical engineering bioimaging /biomedical imaging biotin chemical structure function chemical synthesis chromophore fluorescence fluorescence microscopy fluorescent dye /probe hydropathy ionophores technology /technique development

中文摘要

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英文摘要

DESCRIPTION (Adapted from abstract): The project is aimed at understanding how to enhance two-photon absorption cross-sections of organic molecules to develop two-photon fluorophores. This could greatly enhance the applicability of two-photon fluorescence scanning microscopy (TPFSM). Guidelines for the synthesis of suitable molecules include high two-photon absorption cross section, high fluorescence quantum yield, tunable hydrophilicity, incorporation of functional groups for selective labeling, and photochemical stability to prevent rapid bleaching under laser irradiation.

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