EXPERIMENTAL AND THEORETICAL STUDIES OF HYDROGEN BONDING

描述：该领域提案的总体目标是为学生提供 (本科生和研究生)实验和理论研究 在健康相关领域的经验，以追求学术或 职业生涯。这项建议的主要研究主旨是研究 用核磁共振波谱和理论方法研究氢键体系。这个 具体目标是(A)研究浓度、温度和 二元酸的酸性盐上的反离子与它们的 形成分子内和分子间氢键的能力，(B)检查 二元酸盐类分子内氢键的稳定性 用于添加质子剂和氢交换，(C) 通过膨胀研究碳骨架对氢键的影响 目前关于对称性、环大小和杂交的研究 影响，以及(D)确定氢键的空间要求 运用理论方法。

DESCRIPTION: The overall objective of this AREA proposal is to provide students (both undergraduate and graduate) experimental and theoretical research experiences in the health-related fields so as to pursue academic or professional careers. The major research thrust of this proposal is to study hydrogen-bonded systems employing NMR spectroscopy and theoretical methods. The specific aims are (a) to study the effect of concentration, temperature, and counterions on the acid salts of dicarboxylic acids with regard to their ability to form intra- and intermolecular hydrogen bonds, (b) to examine the stability of intramolecular hydrogen bonds in acid salts of dicarboxylic acids towards the addition of protic solvents and deuterium exchange, (c) to investigate the effect of the carbon framework on hydrogen bonding by expanding the current studies so as to probe symmetry, ring-size and hybridization effects, and (d) to determine the spatial requirements for hydrogen bonding using theoretical methods.