DIETARY ANTIOXIDANTS AND INFECTIOUS DISEASE

膳食抗氧化剂与传染病

• 批准号: 6288780
• 负责人: Suzanne G. Leveille
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6288780
• 关键词: antioxidants; ascorbate; carotene; clinical chemistry; clinical research; dietary supplements; female; human subject; infection; information systems; nutrient intake activity; nutrition related tag; patient /disease registry; postmenopause; tocopherols

The purpose of this study is to determine whether higher dietary and supplemental intake of vitamins C or E, or beta-carotene is associated with lower rates of infections in postmenopausal women. The study subjects are enrollees of Group Health Cooperative of Puget Sound (GHC), a large Seattle-based health maintenance organization, and were screenees for the Fracture Intervention Trial (FIT), a randomized trial of alendronate, which was recently approved for treatment of osteoporosis. This study is using automated data from the subjects records at GHC for the study period from 1992 (FIT baseline) through 1997. In addition, medical record reviews of hospital and outpatient chart have been conducted to validate the use of the automated records for identifying hospital associated and outpatient treated infections. Approvals for this research were obtained from the GHC Human Subjects Review Committee and from the FIT Publications Committee. The primary task that is being conducted as part of this contract is the setting up of a dataset to identify the occurrence of infections in the 1,517 study subjects. Data will be obtained from the following GHC automated databases: pharmacy (antibiotic prescriptions), laboratory (urinalysis, complete blood count, cultures), and utilization (ICD-9 codes from hospital discharge summary). Analyses have been completed investigating risk factors for hospital associated infections. The manuscript for these analyses is currently under review at a scientific journal. Through collaboration with professors in the School of Pharmacy at the University of Washington, a new method for identifying antibiotic- treated infections was developed using the automated pharmacy records. A manuscript has been drafted for the analysis which validated the new method through a comparison with infections identified in outpatient medical record reviews, performed on a random sample of subjects charts. Subsequent analyses will examine whether dietary antioxidants reduced the risk for inpatient and community infections. - antioxidants, infections, postmenopausal women - Human Subjects

这项研究的目的是确定是否较高的饮食和补充摄入维生素C或E，或β-胡萝卜素与绝经后妇女感染率较低有关。研究对象是西雅图大型健康维护组织普吉特海湾团体健康合作社（GHC）的注册者，并且是骨折干预试验（FIT）的筛选者，这是一项阿仑膦酸钠的随机试验，最近被批准用于治疗骨质疏松症。本研究使用1992年（FIT基线）至1997年研究期间GHC受试者记录的自动化数据。此外，还对医院和门诊病历进行了审查，以验证自动记录用于识别医院相关感染和门诊治疗感染的用途。本研究获得了GHC人类受试者审查委员会和FIT出版物委员会的批准。作为该合同的一部分，正在进行的主要任务是建立一个数据集，以确定1，517名研究受试者中感染的发生率。将从以下GHC自动化数据库中获取数据：药房（抗生素处方）、实验室（尿分析、全血细胞计数、培养）和使用（来自出院总结的ICD-9代码）。已经完成了医院相关感染风险因素的调查分析。这些分析的手稿目前正在一份科学杂志上进行审查。通过与华盛顿大学药学院的教授合作，开发了一种使用自动药房记录识别抗生素治疗感染的新方法。已经起草了一份分析手稿，通过与门诊病历审查中确定的感染进行比较，对受试者图表进行随机抽样，验证了新方法。随后的分析将检查饮食抗氧化剂是否降低了住院和社区感染的风险。- 抗氧化剂，感染，绝经后妇女-人类受试者