HIV 感染患者中磺胺嘧啶每日给药与每日给药的药代动力学-猫眼课题宝

HIV 感染患者中磺胺嘧啶每日给药与每日给药的药代动力学

批准号：

6289452

负责人：

STEPHEN PISCITELLI

金额：

$0.0万

依托单位：

CLINICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/6289452

关键词：

AIDS therapy HIV infections clinical research dosage drug screening /evaluation human subject pharmacokinetics sulfanilamides

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中文摘要

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英文摘要

This study is an open-label, randomized, cross-over study to compare the pharmacokinetics of sulfadiazine given on twice daily or four times daily schedule. Ten human immunodeficiency virus-infected patients with CD4 counts below 500 will be enrolled. Patients must not hae concurrent opportunistic infections and must be willing to comply with the study regimen. The study is designed to compare pharmacokinetic parameters and serum conentrations of sulfadiazine at two doses: 1000mg QID and 2000 mg BID. Additionally, this study wll assess the safety and tolerance of these dosage regimens. Currently, the study has received IRB approval and will begin enrolling within the next 1 to 2 months.

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