COMBINATION THERAPY FOR CANCER AND AIDS

癌症和艾滋病的联合治疗

• 批准号: 6289203
• 负责人: JOHN N WEINSTEIN
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289203
• 关键词: AIDS therapy; antiAIDS agent; antineoplastics; combination chemotherapy; computer data analysis; computer program /software; computer system design /evaluation; data collection methodology /evaluation; drug screening /evaluation; human therapy evaluation; mathematical model; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; tissue /cell culture; transport inhibitor

This project began with the discovery in our laboratory group of a new possible modulatory combination therapy for AIDS (dideoxynucleoside plus nucleoside transport inhibitor), which we and our collaborators developed through Phase I clinical trials. When we could not find any published method appropriate for the design and analysis of our experiments on this combination therapy, we decided to develop our own. The result was a set of new concepts, algorithms, and computer programs, incorporated into a package called COMBO. The COMBO algorithms for design and analysis of combination therapy now form the central portion of this project, albeit a small fraction of overall effort in the research group. We have used the new algorithms and programs (in both cancer and AIDS research) to design and analyze experiments on combinations involving such agents as suramin, tumor necrosis factor, taxol, dipyridamole, AZT, ddI, ddC, CD4-pseudomonas exotoxin, HIV protease inhibitors, and hydroxyurea, among others. Current applications of COMBO include a collaboration on synergistic gene therapy constructs for treatment of AIDS> - AIDS, Cancer, combination therapy, Therapy, gene therapy,

这个项目开始于我们实验室小组发现的一种新的可能性， 调节 联合治疗艾滋病（双脱氧核苷加核苷转运抑制剂），这是我们和我们的合作者通过I期临床试验开发的。当我们找不到任何已发表的适合设计和分析这种联合治疗实验的方法时，我们决定开发自己的方法。其结果是一套新的概念，算法和计算机程序，被纳入一个名为COMBO的软件包。用于设计和分析联合治疗的COMBO算法现在形成了该项目的核心部分，尽管只是研究小组整体工作的一小部分。我们已经使用了新的算法和程序（在癌症和艾滋病研究），设计和分析实验的组合，包括苏拉明，肿瘤坏死因子，紫杉醇，双嘧达莫，AZT，ddI，ddC，CD 4-假单胞菌外毒素，HIV蛋白酶抑制剂，和羟基脲，等等。COMBO目前的应用包括用于治疗艾滋病、癌症、联合治疗、治疗、基因治疗的协同基因治疗构建体的合作，