COMBINATION THERAPY FOR CANCER AND AIDS

该项目始于我们实验室小组发现的一种新的可能的艾滋病调节性联合疗法(双脱氧核苷加核苷转运抑制剂)，我们和我们的合作者通过I期临床试验开发了这一疗法。当我们找不到任何公开发表的方法来设计和分析我们关于这种联合疗法的实验时，我们决定开发自己的方法。结果是一系列新的概念、算法和计算机程序被整合到一个名为COMBO的包中。用于设计和分析联合疗法的组合算法现在构成了该项目的核心部分，尽管在研究组的总体工作中只占一小部分。我们已经使用新的算法和程序(在癌症和艾滋病研究中)设计和分析了涉及苏拉明、肿瘤坏死因子、紫杉醇、潘生丁、AZT、DDI、ddC、CD4-假单胞菌外毒素、HIV蛋白酶抑制剂和羟基脲等药物的组合实验。COMBO目前的应用包括在用于治疗艾滋病的协同基因治疗结构上的合作-艾滋病、癌症、联合治疗、治疗、基因治疗、

This project began with the discovery in our laboratory group of a new possible modulatory combination therapy for AIDS (dideoxynucleoside plus nucleoside transport inhibitor), which we and our collaborators developed through Phase I clinical trials. When we could not find any published method appropriate for the design and analysis of our experiments on this combination therapy, we decided to develop our own. The result was a set of new concepts, algorithms, and computer programs, incorporated into a package called COMBO. The COMBO algorithms for design and analysis of combination therapy now form the central portion of this project, albeit a small fraction of overall effort in the research group. We have used the new algorithms and programs (in both cancer and AIDS research) to design and analyze experiments on combinations involving such agents as suramin, tumor necrosis factor, taxol, dipyridamole, AZT, ddI, ddC, CD4-pseudomonas exotoxin, HIV protease inhibitors, and hydroxyurea, among others. Current applications of COMBO include a collaboration on synergistic gene therapy constructs for treatment of AIDS> - AIDS, Cancer, combination therapy, Therapy, gene therapy,