REGULATION OF SKELETAL GROWTH

我们继续寻找调节生长板内软骨内骨形成的关键旁分泌因子。在过去的一年里，我们重点研究了四种细胞外信号分子，维甲酸、C型利钠肽、骨形态发生蛋白-2和钙离子，研究它们对生长板软骨细胞增殖、分化和软骨基质产生的影响。我们还探索了控制生长板软骨细胞空间组织的机制。我们的发现表明，这种空间组织并不依赖于来自周围骨骼的信号，而是依赖于生长板定向因子，该因子起源于生长板软骨本身的休息区。正在进行的研究检查雌激素引起骨骺融合的机制、生长板干细胞的特性以及骨骼生长和骨质疏松症之间的关系。-骨、软骨、生长、平板、软骨细胞、身高、骨质疏松症

We have continued our search to identify the key paracrine factors regulating endochondral bone formation in the growth plate. In the past year, we focused on four extracellular signaling molecules, retinoic acid, C-type natriuretic peptide, bone morphogenetic protein-2 and Ca2+, examining their effects on growth plate chondrocyte proliferation, differentiation, and cartilage matrix production. We have also explored the mechanisms governing spatial organization of growth plate chondrocytes. Our findings suggest that this spatial organization is not dependent on signals from the surrounding bone but rather on a growth plate-orienting factor that originates in the resting zone of the growth plate cartilage itself. Ongoing studies examine the mechanisms by which estrogen causes epiphyseal fusion, the identity of the growth plate stem cell, and the relationships between skeletal growth and osteoporosis. - bone, cartilage, growth, plate, chondrocytes, stature, osteoporosis