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POSITIONAL CLONING OF MEN1 GENE

POSITIONAL CLONING OF MEN1 GENE
MEN1 基因的定位克隆
批准号：
6290274
负责人：
S C CHANDRASEKHARAPPA
金额：
$0.0万
依托单位：
NATIONAL HUMAN GENOME RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6290274
关键词：
artificial chromosomes autosomal dominant trait fluorescent in situ hybridization gene expression gene mutation genetic library genetic mapping genetic markers human genetic material tag linkage disequilibriums loss of heterozygosity molecular cloning multiple endocrine neoplasia neoplasm /cancer genetics nucleic acid probes nucleic acid sequence sequence tagged sites

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中文摘要
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英文摘要
We have shown that inherited mutations in the MEN1 gene predispose individuals to develop multiple endocrine neoplasia type 1 (MEN1), characterized by multiple tumors of the parathyroid, gastrointestinal (GI) endocrine, and anterior pituitary tissues. We have shown that the MEN1 encoded protein (menin) is located primarily in the nucleus, and it interacts with JunD, a member of the AP1 family transcription factors. The menin-JunD interaction results in the repression of JunD- induced transcription, and the protein domains involved in their interaction have been identified. Also, potential interactions of menin with other cellular proteins are being investigated by the yeast two- hybrid system, co-immunoprecipitation and GST?menin pull-down assays. MEN1 homologous genes from mouse, zebrafish and Drosophila have been identified. In order to understand the functional role of menin, a mouse knockout model is being generated by homologous recombination, using the cre-lox system to allow tissue specific inactivation. - Cancer Research
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IDENTIFICATION OF THE GENE(S) RESPONSIBLE FOR ALAGILLE SYNDROME
POSITIONAL CLONING OF MEN1 GENE
POSITIONAL CLONING OF MEN1 GENE
POSITIONAL CLONING OF MEN1 GENE
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