Aortic Root Volume Measurements in Patients using Real Time 3D Echocardiography

使用实时 3D 超声心动图测量患者的主动脉根部体积

• 批准号: 6228026
• 负责人: JULIO PANZA
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6228026
• 关键词: aorta; bioimaging /biomedical imaging; cardiovascular imaging /visualization; clinical research; echocardiography; human subject; intracardiac volume; magnetic resonance imaging

Real time three-dimensional echocardiography (RT3D echo) is a novel technique that provides non-invasive volumetric imaging of cardiac structures. This study was undertaken to determine the feasibility and accuracy of volume measurements of the ascending aorta with RT3D echo. To this end, 21 patients (age: 54+/-17 years; 13 men and 8 women) with different cardiac conditions underwent RT3D echo and multiphase breath- hold cine GRE magnetic resonance imaging (MRI) examinations in random order on the same day. RT3D echo images were acquired from the parasternal window. Images of the ascending aorta were analyzed by independent observers blinded to the results obtained with the other technique. Volume measurements from RT3D echo images were performed with an interactive aided manual tracing technique based on a Silicon Graphics workstation using customized software. The length of the ascending aorta that could be measured from the RT3D echo images ranged from 3.02 to 6.82 cm (mean+/-SD: 4.5+/-1.0). Because the first 3 cm of the ascending aorta could be imaged in every patient, the volume of the proximal 3 cm of the aortic root was compared with the corresponding MRI measurement. The aortic root volumes ranged from 11.0 to 36.9 ml (mean+/-SD: 22.3+/-6.5) by MRI and from 13.1 to 36.2 ml (mean+/-SD: 20.7+/-5.8). A strong correlation was observed between aortic root volume measurements obtained with MRI and with RT3D echo images (r=0.87; y=3.34+0.78x; SEE=2.9 ml). The difference between the two measurements was -1.7+/-3.2 ml. Thus, RT3D echo images of the ascending aorta allow volumetric measurements of the proximal 3 cm of the aortic root in all patients. These measurements strongly correlate with those derived from MRI images and may therefore be useful in the non-invasive evaluation of patients with aortic root disorders. - three-dimensional echocardiography; aortic root - Human Subjects

真实的时间三维超声心动图（RT 3D echo）是一种新的技术，它提供了心脏结构的无创容积成像。本研究旨在确定使用RT 3D回波测量升主动脉容积的可行性和准确性。为此，21名患有不同心脏疾病的患者（年龄：54+/-17岁; 13名男性和8名女性）在同一天随机接受了RT 3D回波和多相屏气电影GRE磁共振成像（MRI）检查。从胸骨旁窗获取RT 3D回波图像。升主动脉的图像由独立观察者进行分析，这些观察者对其他技术获得的结果不知情。采用基于Silicon Graphics工作站的交互式辅助手动描记技术，使用定制软件，对RT 3D回波图像进行体积测量。可从RT 3D超声图像测量的升主动脉长度范围为3.02 - 6.82 cm（平均值+/-SD：4.5+/-1.0）。因为每个患者的升主动脉的前3cm都可以成像，所以将主动脉根部近端3cm的体积与相应的MRI测量值进行比较。MRI显示的主动脉根体积范围为11.0 - 36.9 ml（平均值+/-SD：22.3+/-6.5），MRI显示的主动脉根体积范围为13.1 - 36.2 ml（平均值+/-SD：20.7+/-5.8）。观察到MRI和RT 3D回波图像获得的主动脉根部体积测量值之间存在强相关性（r=0.87; y=3.34+0.78x; SEE=2.9 ml）。两次测量值之间的差异为-1.7+/-3.2 ml。因此，升主动脉的RT 3D回波图像允许对所有患者的主动脉根近端3 cm进行体积测量。这些测量结果与MRI图像的测量结果密切相关，因此可能有助于对主动脉根部疾病患者进行无创评估。- 三维超声心动图;主动脉根部-人类受试者