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NOVAL HUMAN MACROPHAGE RECEPTOR

NOVAL HUMAN MACROPHAGE RECEPTOR
新型人类巨噬细胞受体
批准号：
6290585
负责人：
JUAN M SAAVEDRA
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6290585
关键词：
brain cell experimental brain lesion genetic library human genetic material tag human tissue laboratory rat macrophage microglia molecular cloning nerve injury neural degeneration receptor binding receptor expression

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英文摘要
We are continuing our efforts to clone the novel macrophage receptor form cDNA libraries obtained from human monocytes and from rat spleen. We have found, using quantitative autoradiography with selective iodinated ligands, that the novel macrophage receptor is expressed in the rat brain only after brain lesions resulting in cell death, such as chemical lesions of the inferior olive. The receptor expression is proportional to the degree of brain injury and to the number of injured neurons in this model. These observations indicate that determination of the expression of the novel macrophage receptor may be used as a quantitative method to estimate the degree of brain damage and neuronal death. - human macrophages/cloning/immunology/brain injury
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